Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy

  • US 7,851,506 B2
  • Filed: 07/13/2007
  • Issued: 12/14/2010
  • Est. Priority Date: 12/23/1998
  • Status: Expired due to Term
First Claim
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1. A method of treating a condition responsive to sodium gamma-hydroxybutyrate, comprising orally administering to a patient afflicted with the condition an aqueous composition comprising a first dose of about 4.5 to about 10 grams of sodium gamma-hydroxybutyrate within an hour prior to initial sleep onset and an aqueous composition comprising a second dose of about 4.5 to about 10 grams within 2 to 5 hours following initial sleep onset, wherein the aqueous composition of the first dose and the aqueous composition of the second dose each comprises a respective concentration of sodium gamma-hydroxybutyrate of greater than about 500 mg/mL, wherein the condition is selected from the group consisting of apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.

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