Extended release formulation of levetiracetam

  • US 7,858,122 B2
  • Filed: 08/31/2005
  • Issued: 12/28/2010
  • Est. Priority Date: 01/27/2005
  • Status: Active Grant
First Claim
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1. An extended release tablet of levetiracetam consisting of:

  • from about 30% w/w to about 85% w/w of levetiracetam;

    from about 20% w/w to about 40% w/w of a water dispersible rate controlling polymer having a viscosity greater than 15 cps in a 2% w/w solution and selected from the group consisting of hydroxyethyl cellulose, hydroxypropyl cellulose, sodium alginate, carbomer, sodium carboxymethyl cellulose, xanthan gum, guar gum, locust bean gum, polyvinyl acetate, polyvinyl alcohol, hydroxypropyl methylcellulose and mixtures thereof;

    optionally a binder selected from the group consisting of polyvinyl pyrrolidone, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methyl cellulose, polyacryl amide, poly-N-vinyl amide, sodium carboxymethyl cellulose, polyethylene glycol, gelatin, polyethylene oxide, poly propylene glycol, tragacanth, alginic acid, and combinations thereof;

    optionally one or more lubricants, anti adherents, or glidants, either alone or in combination; and

    optionally a non-functional coating comprising hydrophilic film forming polymer, colorant and opacifying agent,wherein the tablet has the following dissolution profile in USP Apparatus 1 (basket) at 100 rpm in purified water at 37°

    C.;

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