Analyte measuring device

  • US 7,860,545 B2
  • Filed: 02/26/2008
  • Issued: 12/28/2010
  • Est. Priority Date: 03/04/1997
  • Status: Expired due to Fees
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First Claim
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1. A device for subcutaneous monitoring of glucose levels, comprising:

  • a housing;

    a sensor; and

    a porous biointerface layer for promoting long term microcirculatory delivery of glucose and oxygen to the sensor for a time period of at least about one month, wherein the porous biointerface layer comprises an architecture that supports tissue ingrowth and is configured to maintain sufficient fluid flow to the sensor for long term glucose measurement, wherein the porous biointerface layer further comprises a first bioactive agent configured to be released over a first time period of from about one day to about one month, wherein release of the first bioactive agent is configured to increase a rate at which the device becomes functional by at least partially overcoming sleep period effects associated with a temporary decrease in sensor sensitivity associated with tissue ingrowth into the porous biointerface layer;

    wherein the porous biointerface layer further comprises a second bioactive agent configured to be released over a second time period, wherein release of the second bioactive a ent is configured to modulate a foreign body response to reduce a continual decline in sensor sensitivity over a life of a sensor.

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