Pharmaceutical composition containing fenofibrate and method for the preparation thereof

  • US 7,863,331 B2
  • Filed: 10/03/2003
  • Issued: 01/04/2011
  • Est. Priority Date: 07/09/1999
  • Status: Expired due to Term
First Claim
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1. A method of reducing food effect when treating hypertriglyceridemias and/or hypercholesterolemias and/or hyperlipidemias in a patient in need thereof comprising administering to said patient a therapeutically effective amount of a pharmaceutical composition comprising micronized fenofibrate, a surfactant and hydroxypropylmethylcellulose, wherein said composition is in the form of granules comprising:

  • (a) a neutral core; and

    (b) an active layer, surrounding the neutral core;

    wherein said neutral core comprises a sugar or a sugar mixed with starch;

    said active layer comprises the micronized fenofibrate, the surfactant, and the binding cellulose derivative; and

    wherein the mass ratio of said fenofibrate to said hydroxypropylmethylcellulose is between 5/1 and 15/1, and said hydroxypropylmethylcellulose represents between 5 and 12% by weight of the composition.

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