Closed loop neural stimulation synchronized to cardiac cycles
First Claim
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1. A system, comprising:
- a reference event detection circuit configured to receive an input from a reference signal sensor and generate a synchronization control signal using a detected cardiac activity event;
a feedback detection circuit configured to receive an input from at least one feedback sensor and generate a feedback control signal, wherein the at least one feedback sensor is configured to sense cardiac activity including heart rate, and;
a stimulation control circuit configured to generate a stimulation control signal, the stimulation control circuit including a synchronization circuit responsive to the synchronization control signal to time the stimulation control signal, the stimulation control circuit further including a therapy titration circuit responsive to the feedback control signal to adjust the stimulation control signal; and
a stimulation output circuit responsive to the stimulation control signal from the stimulation control circuit and configured to generate a neural stimulation signal for use in stimulating at least one autonomic neural target,wherein the stimulation control circuit is configured to receive sensed heart rate from the feedback detection circuit before controlling the stimulation output circuit to generate the neural stimulation signal, to control the stimulation output circuit to generate the neural stimulation signal, and to titrate the neural stimulation signal to maintain heart rate, andwherein the stimulation control circuit is configured to change a stimulation vector to maintain heart rate.
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Abstract
Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
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Citations
29 Claims
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1. A system, comprising:
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a reference event detection circuit configured to receive an input from a reference signal sensor and generate a synchronization control signal using a detected cardiac activity event; a feedback detection circuit configured to receive an input from at least one feedback sensor and generate a feedback control signal, wherein the at least one feedback sensor is configured to sense cardiac activity including heart rate, and; a stimulation control circuit configured to generate a stimulation control signal, the stimulation control circuit including a synchronization circuit responsive to the synchronization control signal to time the stimulation control signal, the stimulation control circuit further including a therapy titration circuit responsive to the feedback control signal to adjust the stimulation control signal; and a stimulation output circuit responsive to the stimulation control signal from the stimulation control circuit and configured to generate a neural stimulation signal for use in stimulating at least one autonomic neural target, wherein the stimulation control circuit is configured to receive sensed heart rate from the feedback detection circuit before controlling the stimulation output circuit to generate the neural stimulation signal, to control the stimulation output circuit to generate the neural stimulation signal, and to titrate the neural stimulation signal to maintain heart rate, and wherein the stimulation control circuit is configured to change a stimulation vector to maintain heart rate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A system, comprising:
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a reference event detection circuit configured to receive an input from a reference signal sensor and generate a synchronization control signal using a detected cardiac activity event; a feedback detection circuit configured to receive an input from a feedback sensor and generate a feedback control signal, wherein the feedback sensor includes a sensor adapted to detect heart sounds and is configured to sense cardiac activity including heart rate; a stimulation control circuit configured to generate a stimulation control signal, the stimulation control circuit including a synchronization circuit responsive to the synchronization control signal to time the stimulation control signal, the stimulation control circuit further including a therapy titration circuit responsive to the feedback control signal to use detected heart sounds as feedback for adjusting the stimulation control signal; and a stimulation output circuit responsive to the stimulation control signal from the stimulation control circuit and configured to generate a neural stimulation signal for use in stimulating at least one autonomic neural target, wherein the stimulation control circuit is configured to change a stimulation vector to maintain heart rate. - View Dependent Claims (27, 28, 29)
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Specification