Device for calculating blood flow in an extracorporeal blood circuit, and an apparatus for treatment of blood using the device

• US 7,875,168 B2
• Filed: 10/28/2004
• Issued: 01/25/2011
• Est. Priority Date: 10/29/2003
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Zaccarelli, Massimo, Letteri, Jeffrey J., Fressinet, Jean Louis, Artioli, Gianluca
• Primary Examiner(s): Drodge; Joseph W
• Application Number:
  US10/975,082
• Publication Number:
  US 20050095171A1
• Time in Patent Office: 2,280 Days
• Field of Search: 210/86, 210/87, 210/97, 210/101, 210/103, 210/134, 210/646, 210/198.1, 210/321.6, 210/321.65, 210/645, 604/5.01, 604/6.09, 604/30, 604/65, 604/67, 604/131, 604/246, 604/6.01, 604/19, 604/27, 604/28, 604/31, 417 2- 6, 417 18- 22, 417/42, 417/43, 417/44.1
• US Class Current: 210/87
• CPC Class Codes: A61M 1/3441 Substitution rate control as a function of the ultrafiltration rate
• CPC Class Codes: A61M 1/3663 Flow rate transducers; Flow integrators
• CPC Class Codes: A61M 1/3672 Means preventing coagulation

Abstract

The invention relates to a device for calculating blood flow and to an apparatus for extracorporeal blood treatment provided with the device. The device includes a memory for receiving and storing either a first datum relating to a blood flow removed from the patient Q_b, or a second datum relating to a flow of liquid Qt crossing a tract of the extracorporeal circuit, and a third datum relating to a flow of infusion liquid Q_inf flowing through the infusion line. The device also comprises a control unit able to calculate the first datum or the second datum as a function of the third datum relating to the flow of infusion liquid Q_inf.

Claims

1. An apparatus for extracorporeal blood treatment, comprising:

at least one blood treatment unit having a first chamber and a second chamber separated by a semi-permeable membrane;

an extracorporeal circuit for circulation of blood, said extracorporeal circuit comprising a blood removal branch and a blood return branch, said blood removal branch having an end destined to be connected with a cardiovascular system of a patient and another end in communication with an inlet of said first chamber, said blood return branch having an end destined to be connected to a cardiovascular system of a patient and another end in communication with an outlet of said first chamber;

first movement means operating on a post-infusion tract of said blood removal branch, said first movement means causing a flow of liquid across said extracorporeal circuit;

an infusion line connected to said blood removal branch at a section thereof located upstream of said post-infusion tract with reference to a blood circulation direction of blood in said extracorporeal circuit;

second movement means operating on said infusion line for causing a flow of infusion liquid across the infusion line;

a blood flow calculation device comprising;

a memory for receiving and storing a first datum or a second datum and for receiving and storing a third datum, said first datum relating to a flow of blood removed from the patient, said second datum being the flow of liquid across said post-infusion tract, and said third datum relating to a flow of infusion liquid flowing through said infusion line;

first sensor means predisposed to emit a first signal relating to an actual value of the flow of liquid across said post-infusion tract;

a user interface predisposed to receive in input said first datum, said first datum comprising a set value of the blood flow removed from the patient; and

a control unit connected to said memory and to said user interface, said control unit being programmed to calculate said second datum as a function of said first datum and said third datum,

said control unit being connected to said first sensor means,

said control unit being programmed to cooperate with the first and second movement means for bringing the actual value of the flow of liquid across said post-infusion tract towards a set value of the flow of liquid across the same post infusion tract or towards said calculated second datum.

2. The apparatus of claim 1, wherein:

said first datum comprises a set value of (Q_bs) of the blood flow removed from the patient;

said second datum comprises a calculated value (Q_tc) of the flow liquid crossing the said post-infusion tract;

said third datum comprises a set value (Q_infs) of the infusion flow; and

said control unit is programmed to determine the calculated value of the liquid flow using equation Q_tc=Q_infs+(Q_bs).

3. The apparatus of claim 2, wherein said control unit is programmed to receive said first signal and to cooperate with said first movement means in order to bring the actual flow of liquid (Q_tr) across said post-infusion tract towards the calculated value (Q_tc) of the liquid flow.

4. The apparatus of claim 2, comprising second sensor means connected to said control unit and predisposed to provide a second signal relating to an actual value (Q_infr) of the flow of liquid crossing the infusion line.

5. The apparatus of claim 4, wherein the control unit is programmed to cooperate with said second movement means in order to bring the actual flow of infusion liquid towards the set value (Q_infs).

6. The apparatus of claim 2, wherein the control unit is programmed to cooperate with said second movement means in order to bring the actual flow of infusion liquid towards the set value (Q_infs).

7. The apparatus of claim 2, wherein the control unit is programmed to receive the first signal and to cooperate with the first movement means for bringing the actual liquid flow (Q_tr) across said post-infusion tract towards the set value (Q_ts) of the flow of liquid.

8. The apparatus of claim 1, wherein:

said first datum comprises a set value of (Q_bs) of the blood flow removed from the patient;

said second datum comprises a calculated value (Q_tc) of the flow liquid crossing said post-infusion tract;

said third datum comprises an actual value (Q_infr) of the infusion flow; and

said control unit is programmed to determine the calculated value of the liquid flow using equation Q_tc=Q_infr+(Q_bs).

9. The apparatus of claim 1, wherein the user interface is predisposed to display at least one value of the following values:

set value (Q_bs) of blood flow removed from patient;

set value (Q_ts) of liquid flow crossing the post-infusion tract;

set value (Q_infs) of infusion flow;

calculated value (Q_tc) of liquid flow crossing the post-infusion tract;

calculated value (Q_bc) of blood flow removed from the patient;

actual value (Qbr) of blood flow removed from the patient;

actual value (Q_tr) of liquid flow crossing the post-infusion tract;

actual value (Q_infr) of infusion flow.

10. The apparatus of claim 9, wherein the user interface is predisposed to receive in input at least one value of the following values which can be pre-set by a user:

set value (Q_ts) of liquid flow crossing the post-infusion tract;

set value (Q_infs) of infusion flow.

11. The apparatus of claim 1, wherein said control unit is programmed to receive and store in the memory at least one value from the following values:

a desired value relating to a quotient between the infusion flow (Q_inf) and the flow of blood removed from the patient, the value being fixed or obeying a pre-set time rule;

or

a desired value relating to a quotient between the infusion flow (Q_inf) and the flow of liquid crossing the tract, the value being fixed or according to a pre-set time rule.

12. The apparatus of claim 11, wherein the user interface enables the user to change at least one value of the following values during the extracorporeal treatment:

set value (Q_bs) of blood flow removed from patient;

set value (Q_ts) of liquid flow crossing the post-infusion tract;

set value (Q_infs) of infusion flow;

the control unit being programmed to cooperate with at least one of the first and second movement means for maintaining the quotient between the infusion flow (Q_inf) and the blood flow removed from the patient at a level corresponding to a respective desired value.

13. The apparatus of claim 11, wherein the user interface enables the user to change at least one value of the following values during the extracorporeal treatment:

set value (Q_bs) of blood flow removed from patient;

set value (Q_ts) of liquid flow crossing said post-infusion tract;

set value (Q_infs) of infusion flow;

the control unit being programmed to cooperate with at least one of the first and second movement means for maintaining the quotient between the infusion flow (Q_inf) and the flow of liquid crossing the post-infusion tract at a level corresponding to a respective desired value.

14. The apparatus of claim 1, wherein the infusion liquid comprises anticoagulant.

15. The apparatus of claim 1, wherein the first movement means comprise a first pump operating on the blood removal branch.

16. The apparatus of claim 1, wherein the second movement means comprise a second pump operating on the infusion line.

17. The apparatus of claim 1, wherein the infusion line comprises at least one container of a liquid to be infused.

18. The apparatus of claim 1, comprising second sensor means connected to said control unit and predisposed to provide a second signal relating to an actual value (Q_infr) of the flow of liquid crossing the infusion line, said second sensor means comprising a weight sensor operatively associated to the container and predisposed to send a signal to the control unit, said signal corresponding to an updated weight of the container.

19. The apparatus of claim 1, comprising first sensor means connected to said control unit and predisposed to emit a first signal relating to an actual value (Q_tr) of the flow of liquid across said post-infusion tract, said first sensor means comprising a liquid flow sensor associated to the blood removal branch, and located downstream of a section of connection between the infusion line and the extracorporeal circuit.

20. The apparatus of claim 1, comprising first sensor means connected to said control unit and predisposed to emit a first signal relating to an actual value (Q_tr) of the flow of liquid across said post-infusion tract, said first sensor means comprising a velocity sensor associated to the first movement means and configured to send a signal to the control unit, said signal relating to an angular velocity of the first movement means.

21. The apparatus of claim 1, wherein the control unit is programmed to calculate an actual value of the flow of liquid (Q_tr) across said post-infusion tract as a function of the signal relating to an angular velocity of the first movement means, of a signal relating to an existing pressure upstream of the post-infusion tract, of geometric characteristics of the blood removal branch and of a time variable.

22. An apparatus for extracorporeal blood treatment, comprising:

at least one blood treatment unit having a first chamber and a second chamber separated by a semi-permeable membrane;

an extracorporeal circuit for circulation of blood, said extracorporeal circuit comprising a blood removal branch and a blood return branch, said blood removal branch having an end destined to be connected with a cardiovascular system of a patient and another end in communication with an inlet of said first chamber, said blood return branch having an end destined to be connected to a cardiovascular system of a patient and another end in communication with an outlet of said first chamber;

first movement means operating on a post-infusion tract of said blood removal branch, said first movement means causing a flow of liquid across said extracorporeal circuit;

an infusion line connected to said blood removal branch at a section thereof located upstream of said post-infusion tract with reference to a blood circulation direction of blood in said extracorporeal circuit;

second movement means operating on said infusion line for causing a flow of infusion liquid across the infusion line; and

a blood flow calculation device comprising;

a memory for receiving and storing a first datum or a second datum and for receiving and storing a third datum, said first datum relating to a flow of blood removed from the patient, said second datum being the flow of liquid across said post-infusion tract, and said third datum relating to a flow of infusion liquid flowing through said infusion line;

first sensor means predisposed to emit a first signal relating to an actual value of the flow of liquid across said post-infusion tract;

a user interface predisposed to receive in input said first datum, said first datum comprising a set value of the blood flow removed from the patient, and said third datum comprising a set value of the flow of infusion liquid lowing through said infusion line, and

said blood flow calculation device further comprising a control unit connected to said memory and to said user interface, said control unit being programmed to calculate said second datum as a function of said first datum and said third datum,

said control unit being connected to said first sensor means,

said control unit being programmed to cooperate with the first and second movement means for bringing the actual value of the flow of liquid across said post-infusion tract towards a set value of the flow of liquid across the same post infusion tract or towards said calculated second datum.

23. An apparatus for extracorporeal blood treatment, comprising:

at least one blood treatment unit having a first chamber and a second chamber separated by a semi-permeable membrane;

an extracorporeal circuit for circulation of blood, said extracorporeal circuit comprising a blood removal branch and a blood return branch, said blood removal branch having an end destined to be connected with a cardiovascular system of a patient and another end in communication with an inlet of said first chamber, said blood return branch having an end destined to be connected to a cardiovascular system of a patient and another end in communication with an outlet of said first chamber;

first movement means operating on a post-infusion tract of said blood removal branch, said first movement means causing a flow of liquid across said extracorporeal circuit;

an infusion line connected to said blood removal branch at a section thereof located upstream of said post-infusion tract with reference to a blood circulation direction of blood in said extracorporeal circuit;

second movement means operating on said infusion line for causing a flow of infusion liquid across the infusion line; and

a blood flow calculation device comprising;

a memory for receiving and storing a first datum or a second datum and for receiving and storing a third datum, said first datum relating to a flow of blood removed from the patient, said second datum being the flow of liquid across said post-infusion tract, and said third datum relating to a flow of infusion liquid flowing through said infusion line;

first sensor means predisposed to emit a first signal relating to an actual value of the flow of liquid across said post-infusion tract; and

a user interface predisposed to receive in input said first datum, said first datum comprising a set value of the blood flow removed from the patient,

said user interface being also predisposed to receive in input said third datum, said third datum comprising a value of the flow of infusion liquid flowing through said infusion line, or a ratio between the blood flow removed from the patient and the value of the flow of infusion liquid flowing through said infusion line, and

said blood flow calculation device further comprising a control unit connected to said memory and to said user interface, said control unit being programmed to calculate said second datum as a function of said first datum and said third datum,

said control unit being connected to said first sensor means,

said control unit being programmed to cooperate with the first and second movement means for bringing the actual value of the flow of liquid across said post-infusion tract towards a set value of the flow of liquid across the same post infusion tract or towards said calculated second datum.