Biointerface membranes incorporating bioactive agents

  • US 7,875,293 B2
  • Filed: 05/10/2004
  • Issued: 01/25/2011
  • Est. Priority Date: 05/21/2003
  • Status: Active Grant
  • ×
    • Pin Icon | RPX Insight
    • Pin
First Claim
Patent Images

1. An implantable glucose sensor having a biointerface membrane comprising:

  • a first domain comprising a nonresorbable solid portion comprising a plurality of interconnected cavities having a pore size greater than about 30 μ

    m, as determined by a bubble point test measurement, wherein the solid portion is adapted to support a tissue ingrowth in vivo;

    a second domain located adjacent to the first domain, wherein the second domain is impermeable to cells or cell processes and is configured to allow a passage of glucose therethrough; and

    a bioactive agent incorporated into the biointerface membrane, wherein the bioactive agent is capable of modifying a tissue response in such a way that sleep period effects on the implantable glucose sensor are reduced, wherein the bioactive agent is configured to be released from the first domain and/or the second domain.

View all claims
  • 1 Assignment