Antibodies that immunospecifically bind to B lymphocyte stimulator

  • US 7,879,328 B2
  • Filed: 02/10/2005
  • Issued: 02/01/2011
  • Est. Priority Date: 06/16/2000
  • Status: Active Grant
First Claim
Patent Images

1. A method of antagonizing B Lymphocyte Stimulator activity in an animal having systemic lupus erythematosus or rheumatoid arthritis comprising administering to the animal an antibody comprising a first amino acid sequence that is at least 85% identical to amino acid residues 1-123 of SEQ ID NO:

  • 327 and a second amino acid sequence that is at least 85% identical to amino acid residues 141-249 of SEQ ID NO;

    327, and wherein the antibody binds B Lymphocyte Stimulator selected from the group consisting of;

    (a) amino acid residues 1-285 of SEQ ID NO;

    3228;

    (b) amino acid residues 134-285 of SEQ ID NO;

    3228; and

    (c) a trimer comprising amino acid residues 134-285 of SEQ ID NO;

    3228.

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