Thoracic impedance detection with blood resistivity compensation

• US 7,881,781 B2
• Filed: 12/01/2009
• Issued: 02/01/2011
• Est. Priority Date: 08/19/2004
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Moon, Boyce, Stahmann, Jeffrey E., Hatlestad, John D.
• Primary Examiner(s): Nasser; Robert L
• Application Number:
  US12/628,384
• Publication Number:
  US 20100076336A1
• Time in Patent Office: 427 Days
• Field of Search: None
• US Class Current: 600/547
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

This document discusses, among other things, a cardiac rhythm management device or other implantable medical device that uses thoracic impedance to determine how much fluid is present in the thorax, such as for detecting or predicting congestive heart failure, pulmonary edema, pleural effusion, hypotension, or the like. The thoracic fluid amount determined from the thoracic impedance is compensated for changes in blood resistivity, which may result from changes in hematocrit level or other factors. The blood-resistivity-compensated thoracic fluid amount can be stored in the device or transmitted to an external device for storage or display. The blood-resistivity-compensated thoracic fluid amount can also be used to adjust a cardiac pacing, cardiac resynchronization, or other cardiac rhythm management or other therapy to the patient. This document also discusses applications of the devices and methods for predicting or indicating anemia.

Claims

1. A method comprising:

obtaining a first blood resistivity quantity during a first time using at least one implanted intravascular or intracardiac electrode in a subject;

obtaining a second blood resistivity quantity during a second time using the at least one implanted intravascular or intracardiac electrode;

comparing, using a controller, the second blood resistivity quantity to the first blood resistivity quantity; and

declaring an indication or prediction of anemia to be present in the patient when the second blood resistivity quantity is less than the first blood resistivity quantity by at least a first amount.

2. The method of claim 1, wherein obtaining the first blood resistivity quantity and obtaining the second blood resistivity quantity are performed in the same blood vessel or heart chamber.

3. The method of claim 1, wherein obtaining the first blood resistivity quantity and obtaining the second blood resistivity quantity are performed under a like condition with respect to at least one of a cardiac cycle, a respiratory cycle, a posture, and a circadian cycle.

4. The method of claim 1, comprising communicating an indication of anemia predicted or anemia present to an external device.

5. The method of claim 1, wherein declaring an indication or prediction of anemia includes:

declaring an indication of anemia to be present in the patient when the second blood resistivity quantity is less than the first blood resistivity quantity by at least a second amount; and

declaring a prediction of anemia to be present in the patient when the second blood resistivity quantity is less than the first blood resistivity quantity by at least the first amount and by less than the second amount.

6. The method of claim 1, comprising communicating information regarding the indication or prediction of anemia.

7. The method of claim 1, comprising displaying information regarding the indication or prediction of anemia.

8. The method of claim 7, wherein displaying the information includes displaying the information using an external device.

9. The method of claim 1, comprising providing an anemia warning with the indication or prediction of anemia.

10. The method of claim 1, wherein at least one of:

obtaining the first blood resistivity quantity includes detecting a first blood resistivity measurement during the first time;

or

obtaining the second blood resistivity quantity includes detecting a second blood resistivity measurement during the second time.

11. The method of claim 1, wherein at least one of:

obtaining the first blood resistivity quantity includes combining two or more first blood resistivity measurements acquired during the first time;

or

obtaining the second blood resistivity quantity includes combining two or more second blood resistivity measurements acquired during the second time.

12. The method of claim 1, wherein at least one of:

obtaining the first blood resistivity quantity includes averaging two or more first blood resistivity measurements acquired during the first time;

or

obtaining the second blood resistivity quantity includes averaging two or more second blood resistivity measurements acquired during the second time.

13. An implantable medical device comprising:

a blood resistivity measurement circuit configured to provide a blood resistivity signal using first and second electrodes;

a controller coupled to the blood resistivity measurement circuit, the controller configured to determine an indication or prediction of anemia by comparing a second blood resistivity quantity to an earlier first blood resistivity quantity; and

a communication circuit coupled to the controller, the communication circuit configured to communicate the indication or prediction of anemia to an external interface device.

14. The implantable medical device of claim 13, wherein the first and second electrodes are located within the same blood vessel or heart chamber.

15. The implantable medical device of claim 13, wherein the first and second electrodes are included on a leadwire.

16. The implantable medical device of claim 15, wherein the first electrode includes a ring electrode and the second electrode includes a tip electrode.

17. The implantable medical device of claim 15, comprising:

a third electrode included on a housing of the implantable medical device; and

a fourth electrode included on the leadwire;

a test current circuit configured to deliver a test current between the third and fourth electrodes; and

a voltage measurement circuit configured to measure a resulting voltage between the first and second electrodes.

18. The implantable medical device of claim 17, wherein the fourth electrode includes a ring electrode.

19. The implantable medical device of claim 13, comprising a heart signal sensing circuit configured to synchronize the first and second times to like portions of different cardiac cycles.

20. The implantable medical device of claim 13, comprising a posture sensor and a posture compensation module configured to store different first blood resistivity quantities corresponding to different postures obtained from the posture sensor.

21. The implantable medical device of claim 13, comprising a thoracic impedance measurement circuit configured to synchronize the first and second times to like portions of different respiration cycles.

22. The implantable medical device of claim 13, wherein at least one of:

the first blood resistivity quantity includes a first blood resistivity measurement detected during the first time;

or

the second blood resistivity quantity includes a second blood resistivity measurement detected during the second time.

23. The implantable medical device of claim 13, wherein at least one of:

the first blood resistivity quantity includes a combination of two or more first blood resistivity measurements acquired during the first time;

or

the second blood resistivity quantity includes a combination of two or more second blood resistivity measurements acquired during the second time.

24. The implantable medical device of claim 13, wherein at least one of:

the first blood resistivity quantity includes an average of two or more first blood resistivity measurements acquired during the first time;

or

the second blood resistivity quantity includes an average of two or more second blood resistivity measurements acquired during the second time.

25. A system comprising:

means for obtaining a first blood resistivity quantity during a first time using at least one implanted intravascular or intracardiac electrode in a subject;

means for obtaining a second blood resistivity quantity during a second time using the at least one implanted intravascular or intracardiac electrode;

means for comparing the second blood resistivity quantity to the first blood resistivity quantity; and

means for declaring an indication or prediction of anemia to be present in the patient when the second blood resistivity quantity is less than the first blood resistivity quantity by at least a first amount.

26. The system of claim 25, wherein the means for declaring the indication or prediction of anemia includes:

means for declaring an indication of anemia to be present in the patient when the second blood resistivity quantity is less than the first blood resistivity quantity by at least a second amount; and

means for declaring a prediction of anemia to be present in the patient when the second blood resistivity quantity is less than the first blood resistivity quantity by at least the first amount and by less than the second amount.

27. The system of claim 25, comprising means for communicating information regarding the indication or prediction of anemia.

28. The system of claim 25, wherein at least one of:

the means for obtaining the first blood resistivity quantity includes means for detecting a first blood resistivity measurement during the first time;

or

the means for obtaining the second blood resistivity quantity includes means for detecting a second blood resistivity measurement during the second time.

29. The system of claim 25, wherein at least one of:

the means for obtaining the first blood resistivity quantity includes means for combining two or more first blood resistivity measurements acquired during the first time;

or

the means for obtaining the second blood resistivity quantity includes means for combining two or more second blood resistivity measurements acquired during the second time.

30. The system of claim 25, wherein at least one of:

the means for obtaining the first blood resistivity quantity includes means for averaging two or more first blood resistivity measurements acquired during the first time;

or

the means for obtaining the second blood resistivity quantity includes means for averaging two or more second blood resistivity measurements acquired during the second time.