Systems and methods for determining intraocular lens power

• US 7,883,208 B2
• Filed: 04/06/2009
• Issued: 02/08/2011
• Est. Priority Date: 04/04/2008
• Status: Active Grant

• Current Assignee: Abbott Medical Optics Incorporated (Johnson & Johnson), Amo Groningen B.V (Johnson & Johnson)
• Original Assignee: Amo Groningen B.V (Johnson & Johnson)
• Inventors: Bergman, Rolf, Norrby, Sverker
• Primary Examiner(s): HASAN, MOHAMMED A
• Application Number:
  US12/419,230
• Publication Number:
  US 20090251664A1
• Time in Patent Office: 673 Days
• Field of Search: 351200-246, 351/160.R, 351/160.H, 351161-162, 351176-177, 623/6, 623/11, 623/6.32, 623/6.28, 623/6.11
• US Class Current: 351/177
• CPC Class Codes: A61B 3/0025 characterised by electronic signal processing, e.g. eye models
• CPC Class Codes: A61B 3/103 for determining refraction, e.g. refractometers, skiascopes
• CPC Class Codes: A61B 3/107 for determining the shape or measuring the curvature of the cornea
• CPC Class Codes: A61F 2/1613 having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus

Abstract

A system for providing an intraocular lens includes a processor and a computer readable memory. The computer readable memory is configured to communicate with the processor, the memory having stored therein at least one of: one or more ocular dimensions, and at least one predetermined refractive outcome. The memory further includes a sequence of instructions which, when executed by the processor, cause the processor to select an intraocular lens, select a power of an intraocular lens, or provide an intraocular lens. The sequence of instructions includes determining one or more dimensions of an eye. The instructions also include calculating, based on a mathematical relationship, a distance from an apex of a cornea of the eye to an apex or plane of the intraocular lens after insertion into the eye. The instructions further calculating an optical power of the intraocular lens suitable for providing a predetermined refractive outcome. The mathematical relationship includes an axial length of the eye, an anterior chamber depth of the natural crystalline lens, and a corneal radius of the eye, but is independent of a thickness of the natural crystalline lens.

Claims

1. A method of selecting an intraocular lens or an optical power thereof, comprising:

providing an eye comprising a cornea and a retina;

determining a value of an axial length of an eye, the axial length being equal to a distance from the apex of the cornea to a surface of the retina;

calculating, based on a mathematical relationship, a distance from the apex to a plane of the intraocular lens after an ocular surgical procedure;

calculating an optical power of the intraocular lens suitable for providing a predetermined refractive outcome;

wherein the mathematical relationship comprises a dependent variable that varies with a value of an independent variable, the independent variable having a base value corresponding to the determined axial length;

wherein the mathematical relationship has a sensitivity of less than or equal to 0.5%, the sensitivity being defined as a percent variation in the dependent variable for a 1% in the base value.

2. The method of claim 1, wherein the mathematical relationship has a sensitivity of less than or equal to 0.6%.

3. The method of claim 1, further comprising at least one of placing the intraocular lens behind the cornea, within the cornea, or on top of the cornea, or forming the intraocular lens from an injectable material behind the cornea, within the cornea, or on top of the cornea.

4. The method of claim 1, wherein the sensitivity is less than or equal to 0.4 percent when the method is used to calculate a position of Tecnis Z9000 intraocular lens after an ocular surgical procedure.

5. The method of claim 1, wherein the mathematical relationship includes an anterior chamber depth prior to an ocular surgical procedure.

6. The method of claim 5, wherein the distance from the apex to a plane of the intraocular lens after an ocular surgical procedure is a dependent variable ACD_post and the mathematical relationship is:

ACD_post=C1+C2×

AL+C3×

ACD_pre+C4×

CR,

where AL is an input parameter representing the axial length of the eye, ACD_pre is an input parameter representing the anterior chamber depth prior to an ocular surgical procedure, CR is an input parameter representing a radius of curvature of the cornea, C1 is a constant with a nominal value of 4.236, C2 is a constant with a nominal value of 0.08495, C3 is a constant with a nominal value of 0.42435, and C4 is a constant with a nominal value of −

0.3945, each of the constants having a value that is within plus or minus 20 percent of the nominal value thereof.

7. The method of claim 5, wherein each of the constants has a value that is within plus or minus 5 percent of the nominal value thereof.

8. The method of claim 5, wherein C1 equals 4.236, C2 equals 0.08495, C3 equals 0.42435, and C4 equals −

0.3945.

9. The method of claim 5, wherein the calculated position is a calculated distance between the cornea and a lens haptic plane of an intraocular lens and the mathematical relationship is:

LHP=C1+C2×

AL+C3×

ACD_pre+C4×

CR,

where LHP is the calculated distance between the cornea and a lens haptic plane, AL is an input parameter representing the axial length of the eye, ACD_pre is an input parameter representing the anterior chamber depth prior to an ocular surgical procedure, CR is an input parameter representing a radius of curvature of the cornea, C1 is a constant with a nominal value of 4.556, C2 is a constant with a nominal value of 0.08495, C3 is a constant with a nominal value of 0.42435, and C4 is a constant with a nominal value of −

0.3945, each of the constants having a value that is within plus or minus 20 percent of the nominal value thereof.

10. The method of claim 5, wherein the calculated position is a calculated anterior chamber depth, ACD_post, and the mathematical relationship is:

ACD_post=C1+C2×

AL+C3×

ACD_pre,

where AL is an input parameter representing the axial length of the eye, ACD_pre is an input parameter representing the anterior chamber depth prior to an ocular surgical procedure, C1 is a constant with a nominal value of 3.18, C2 is a constant with a nominal value of 0.0203, and C3 is a constant with a nominal value of 0.281, each of the constants having a value that is within plus or minus 20 percent of the nominal value thereof.

11. The method of claim 5, wherein the calculated position is a calculated distance between the cornea and a lens haptic plane of an intraocular lens and the mathematical relationship is:

LHP=C1+C2×

AL+C3×

ACD_pre,

where LHP is the calculated distance between the cornea and a lens haptic plane, AL is an input parameter representing the axial length of the eye, ACD_pre is an input parameter representing the anterior chamber depth prior to an ocular surgical procedure, C1 is a constant with a nominal value of 3.50, C2 is a constant with a nominal value of 0.0203, and C3 is a constant with a nominal value of 0.281, each of the constants having a value that is within plus or minus 20 percent of the nominal value thereof.

12. The method of claim 1, wherein the mathematical relationship includes a radius of curvature of the cornea.

13. The method of claim 1, wherein the mathematical relationship is independent of a radius of curvature of the cornea.

14. The method of claim 13, wherein calculating an optical power of the intraocular lens comprises calculating an optical power of an intraocular lens for use with a subject that has previously undergone a corneal refractive procedure.

15. The method of claim 1, wherein the mathematical relationship includes measured or calculated parameters of the eye that are multiplied together.

16. A system for providing an intraocular lens, the system comprising:

a processor; and

a computer readable memory configured to communicate with the processor, the memory having stored therein;

an array of ordered values, including at least one of;

one or more ocular dimensions, the ocular dimensions including an axial length of an eye having a cornea with an apex and a retina surface, the axial length being equal to a first distance from the apex to the retina surface;

a predetermined refractive outcome;

a sequence of instructions which, when executed by the processor, cause the processor to select an intraocular lens, select an optical power of the intraocular lens, or provide the intraocular lens, the sequence of instructions including;

calculating, based on a mathematical relationship, a second distance from the apex to an apex or a plane of the intraocular lens when the intraocular lens is inserted into the eye;

calculating an optical power of the intraocular lens suitable for providing the predetermined refractive outcome;

wherein the mathematical relationship comprises a dependent variable that varies with a value of an independent variable, the independent variable having a base value corresponding to the axial length of the eye;

wherein the mathematical relationship has a sensitivity of less than or equal to 0.5%, the sensitivity defined as a percent variation in the dependent variable for a 1% increase of the independent variable from the base value.

17. A system for providing an intraocular lens, the system comprising:

a processor; and

a computer readable memory configured to communicate with the processor, the memory having stored therein;

an array of ordered values, including at least one of;

one or more ocular dimensions of an eye having a cornea with an apex and a retina surface;

a predetermined refractive outcome;

a sequence of instructions which, when executed by the processor, cause the processor to select an intraocular lens, select an optical power of the intraocular lens, or provide the intraocular lens, the sequence of instructions including;

calculating, based on a mathematical relationship, a distance from the apex to an apex or plane of the intraocular lens when the intraocular lens is inserted into the eye;

calculating an optical power of the intraocular lens suitable for providing the predetermined refractive outcome;

wherein the mathematical relationship includes an independent variable that depends on an axial length of the eye, AL, an anterior chamber depth of the natural crystalline lens, ACD_pre, and a corneal radius of the eye, CR, but is independent of a thickness of the natural crystalline lens, LT.

18. The system of claim 17, wherein the sequence of instructions further comprises:

determining a location of the plane of the intraocular lens;

performing a calculation to determine a predicted refractive outcome based on the eye model and a ray tracing algorithm;

comparing the predicted refractive outcome to the desired refractive outcome;

based on the comparison, repeating the performed calculation with an IOL having at least one of a different power, a different aspheric profile, and a different lens plane.

19. The system of claim 17, wherein the system comprises a phaco emulsification system.

20. The system of claim 17, wherein the calculated distance is a calculated anterior chamber depth after a surgery, ACD_post, and the mathematical relationship is:

ACD_post=C1+C2×

AL+C3×

ACD_pre+C4×

CR,

where AL is an input parameter representing the axial length of the eye, ACD_pre is an input parameter representing the anterior chamber depth prior to an ocular surgical procedure, CR is an input parameter representing a radius of curvature of the cornea, and C1-C4 are constants.

21. The system of claim 20, wherein C1 equals 4.236, C2 equals 0.08495, C3 equals 0.42435, and C4 equals −

0.3945.

22. The system of claim 21, wherein each of the constants has a value that is within plus or minus 5 percent of the nominal value thereof.

23. The system of claim 17, wherein the calculated distance is a calculated distance between the cornea and a lens haptic plane, LHP, of an intraocular lens and the mathematical relationship is:

LHP=C1+C2×

AL+C3×

ACD_pre+C4×

CR,

where LHP is the calculated distance between the cornea and a lens haptic plane, AL is an input parameter representing the axial length of the eye, ACD_pre is an input parameter representing the anterior chamber depth prior to an ocular surgical procedure, CR is an input parameter representing a radius of curvature of the cornea, C1 is a constant with a nominal value of 4.556, C2 is a constant with a nominal value of 0.08495, C3 is a constant with a nominal value of 0.42435, and C4 is a constant with a nominal value of −

0.3945, each of the constants having a value that is within plus or minus 20 percent of the nominal value thereof.

24. The system of claim 23, wherein the calculated position is a calculated anterior chamber depth, ACD_post, and the mathematical relationship is:

ACD_post=C1+C2×

AL+C3×

ACD_pre,

where AL is an input parameter representing the axial length of the eye, ACD_pre is an input parameter representing the anterior chamber depth prior to an ocular surgical procedure, C1 is a constant with a nominal value of 3.18, C2 is a constant with a nominal value of 0.0203, and C3 is a constant with a nominal value of 0.281, each of the constants having a value that is within plus or minus 20 percent of the nominal value thereof.

25. The system of claim 17, wherein the calculated position is a calculated distance between the cornea and a lens haptic plane of an intraocular lens and the mathematical relationship is:

LHP=C1+C2×

AL+C3×

ACD_pre,

where LHP is the calculated distance between the cornea and a lens haptic plane, AL is an input parameter representing the axial length of the eye, ACD_pre is an input parameter representing the anterior chamber depth prior to an ocular surgical procedure, C1 is a constant with a nominal value of 3.50, C2 is a constant with a nominal value of 0.0203, and C3 is a constant with a nominal value of 0.281, each of the constants having a value that is within plus or minus 20 percent of the nominal value thereof.