Multiple ratio fluid dispenser

• US 7,883,501 B2
• Filed: 08/10/2009
• Issued: 02/08/2011
• Est. Priority Date: 06/14/2002
• Status: Expired due to Term

• Current Assignee: Arteriocyte Medical Systems, Inc (Isto Biologics, Inc.)
• Original Assignee: Arteriocyte Medical Systems, Inc (Isto Biologics, Inc.)
• Inventors: Albrecht, Richard M., McIntosh, Kevin D.
• Primary Examiner(s): Mendez; Manuel A
• Application Number:
  US12/462,885
• Publication Number:
  US 20090306623A1
• Time in Patent Office: 547 Days
• Field of Search: 604 82- 86, 604181-182, 604/187, 604/191, 604506-511, 604/500, 604 401- 616, 222/145.5, 222/145.6, 222/137, 222/386
• US Class Current: 604/506
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61C 5/64 for multi-component compositions
• CPC Class Codes: A61M 2005/3139 Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips

Abstract

A double syringe delivery system is disclosed for holding a pair of syringes in a manner so as to accommodate the simultaneous activation of the plunger of each syringe in order to effect simultaneous delivery of the contents of each syringe. The delivery system includes a delivery mechanism for delivering the contents of both syringes to a site of application. The delivery system further includes a support member that is positioned between the two syringe bodies. The elongated support member has resilient, C-shaped clamps on one end of the support member. The clamps are designed to be removably clamped onto the applicator so that the syringe barrels will be held together in a parallel manner. The elongated support member further comprises finger grips. A plunger connects the two syringe plungers so that they can also be simultaneously activated.

Claims

1. A method of delivering a composition to a patient comprising:

centrifuging anticoagulated blood to obtain a platelet rich plasma;

placing a first portion of the platelet rich plasma in a first syringe body;

adding to the first syringe body an agent for reversing the effects of an anticoagulant within the first portion of the platelet rich plasma and allowing a clot to form within the first syringe body;

placing a second portion of platelet rich plasma in a second syringe body;

delivering thrombin from the first syringe body to the patient by squeezing the clot contained in the first syringe body through a filter material; and

delivering simultaneously the second portion of the platelet rich plasma from the second syringe body to the patient to combine with the thrombin delivered to the patient from the first syringe body to form a platelet gel composition.

2. The method of claim 1 wherein the first and second syringe bodies have a luer connector at one end.

3. The method of claim 2 wherein an applicator tip comprising first and second luer fittings is connected to the luer connectors of the first and second syringe bodies.

4. The method of claim 3 further comprising the step of placing the first and second syringe bodies in a holding mechanism that retains the syringe bodies in parallel alignment without contacting said first and second syringe bodies, the holding mechanism comprising an elongated support member positioned between the first and second syringe bodies and having a pair of C-shaped clamps extending laterally from one end of the elongated support member for attachment to the applicator tip luer fittings.

5. The method of claim 1 wherein the first and second syringe bodies have first and second plungers, respectively, for delivering from each of the syringe bodies its associated material, the first and second plungers each having a push flange and a plunger shaft.

6. The method of claim 5 further comprising the step of placing the push flanges of the first and second plungers in a plunger clip having first and second channeled grooves for securing the plunger push flanges within the first and second grooves and actuating the plungers simultaneously.

7. The method of claim 6 wherein the first syringe body has a first length and the second syringe body has a second length, the first syringe body length being a different length than the second syringe body length and the first and second grooves of the plunger clip are longitudinally offset by an amount that is substantially the same as the difference in the lengths of the first and second syringe bodies.

8. The method of claim 1 wherein the platelet gel composition forms within a wound site of the patient.

9. The method of claim 1 wherein the anticoagulant is sodium citrate.

10. The method of claim 1 wherein the anticoagulant is heparin.

11. The method of claim 1 wherein the anticoagulated blood is centrifuged at a rate of about approximately 20 to 50 r.c.f.'"'"'s.

12. The method of claim 1 wherein the anticoagulated blood is centrifuged for about approximately 10 to 40 minutes.

13. The method of claim 1 wherein the anticoagulated blood is centrifuged refrigerated at about 25 r.c.f.'"'"'s for about 20 minutes.

14. The method of claim 1 wherein the first syringe includes a contact activator to speed up the formation of the clot.

15. The method of claim 14 wherein the contact activator is selected from the group consisting of glass, glass wool, silica, aluminum, diatomaceous earth and kaolin.

16. The method of claim 1 wherein the agent for reversing the effects of the anticoagulant is selected from the group consisting of sodium chloride, calcium gluconate and heparinase.

17. The method of claim 1 wherein the filter material is glass wool.