Automatic prime of an extracorporeal blood circuit

• US 7,892,197 B2
• Filed: 09/19/2007
• Issued: 02/22/2011
• Est. Priority Date: 09/19/2007
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Inventors: Folden, Thomas I., Crnkovich, Martin Joseph
• Primary Examiner(s): Deak; Leslie R
• Application Number:
  US11/858,104
• Publication Number:
  US 20090076433A1
• Time in Patent Office: 1,252 Days
• Field of Search: 604/5.04, 604/6.06, 604/6.09, 604/6.1, 604/6.11, 604/6.16
• US Class Current: 604/6.11
• CPC Class Codes: A61M 1/3643 Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3644 Mode of operation
• CPC Class Codes: A61M 1/3647 with recirculation of the priming solution
• CPC Class Codes: A61M 1/3649 using dialysate as priming or rinsing liquid

Abstract

A system for priming an extracorporeal blood circuit is described. The system includes a fluid circuit with an air venting mechanism, a reversible pump, arterial and venous lines, a prime waste bag and a switchable coupler selectively connecting the arterial and venous lines to the waste bag or alternatively interconnecting the arterial and venous lines. A priming fluid is connected to the circuit and circulated in the circuit under different configurations of the arterial and venous line connections.

Claims

1. A method of priming an extracorporeal blood circuit including a venous line, an arterial line and a line to a prime waste container, wherein any two of the venous line, arterial line and line to the waste container can be selectively in fluid communication with each other, and a chamber including a filter that allows air to escape from the chamber, the method comprising:

occluding one of the venous line or the arterial line while connecting the other of the venous or arterial line to the prime waste container;

flowing priming fluid through the circuit so that the priming fluid flows out of either the arterial or venous line into the waste container;

occluding the line to the waste container and connecting the arterial and venous lines together;

circulating priming fluid through the closed extracorporeal circuit;

reversing the flow through the circuit, whereby air is removed from the circuit; and

detecting a liquid level in the chamber to determine whether the extracorporeal blood circuit has been sufficiently primed,

wherein the steps of occluding one of the venous line or the arterial line, flowing priming fluid, occluding the line to the waste container, circulating priming fluid, reversing the flow through the circuit, and detecting the liquid level in the chamber are done without need for human manipulation, and

wherein a liquid entry port and a liquid exit port are in a bottom region of the chamber, and the filter is in a top region of the chamber.

2. The method of claim 1, wherein flowing priming fluid through the circuit forces air in the circuit out of the filter associated with the chamber.

3. The method of claim 1, further comprising reversing direction of flow of the priming fluid in the circuit multiple times, wherein reversing the direction of flow is programmed to be done automatically.

4. The method of claim 1, further comprising:

disconnecting an end of the arterial line; and

connecting the end of the arterial line to a patient.

5. The method of claim 4, further comprising after connecting the arterial line to a patient, flowing blood from the patient into the circuit, wherein the circuit is air-free.

6. The method of claim 5, further comprising maintaining a connection between the waste container and the venous line while flowing blood from the patient into the circuit.

7. The method of claim 6, further comprising:

clamping closed a connection to the prime container after the blood enters the venous line;

disconnecting the venous line from the line to the waste container; and

connecting the venous line to the patient.

8. The method of claim 7, wherein the venous line is disconnected from the line to the waste container after flowing blood from the patient into the circuit.

9. The method of claim 4, further comprising:

disconnecting an end of the venous line when the end of the arterial line is disconnected; and

connecting the end of the venous line to the patient when the end of the arterial line is connected to the patient.

10. The method of claim 1, further comprising:

flowing priming fluid through the circuit to force air in the circuit out of the filter associated with a the chamber in the circuit; and

stopping the circulating once air in the circuit has been eradicated from the circuit to form the air-free circuit.

11. The method of claim 1, wherein:

the circuit includes a dialyzer;

flowing priming fluid through the circuit, reversing the flow through the circuit and forcing air out of the circuit with the fluid define a priming sequence; and

the method does not include inverting the dialyzer during any steps of the priming sequence.

12. The method of claim 1, wherein the filter is a hydrophobic microporous filter.

13. The method of claim 1, further comprising temporarily clamping the venous line while flowing the priming fluid through the circuit to build up pressure in the circuit.

14. The method of claim 1, wherein each of the arterial line, the venous line, and the line to the waste container is equipped with a clamp, and two of the clamps are mechanically linked so that their operation is mutually exclusive such that when one of the two clamps is open, the other of the two clamps is closed.

15. A method of priming an extracorporeal circuit including a venous line, an arterial line and a chamber with a filter that allows air to escape from the chamber while preventing liquid from escaping from the chamber, comprising:

flowing fluid through the circuit in a forward direction and a backward direction, while the arterial line and the venous line define the circuit and a supply of priming solution is in line with the circuit, wherein flowing the fluid forces air out through the filter; and

stopping the flowing after a quantity of fluid sufficient to fill the circuit completely has been released into the circuit and circulated and a level detector has detected a level of liquid in the chamber indicating that there is no longer air in the circuit, and

wherein a liquid entry port and a liquid exit port are in a bottom region of the chamber, and the filter is in a top region of the chamber.

16. The method of claim 15, further comprising:

occluding the arterial line prior to flowing the fluid through the circuit; and

opening the arterial line after flowing the fluid through the circuit in a forward direction, but before flowing the fluid through the circuit in a backward direction.

17. The method of claim 16, further comprising:

opening a connection to a prime container connected to the circuit contemporaneous with occluding the arterial line; and

occluding the connection to the prime container prior to flowing the fluid in the circuit in a backward direction contemporaneous with opening a connection to the arterial line.

18. The method of claim 15, wherein the filter is a hydrophobic microporous filter.

19. The method of claim 15, further comprising temporarily clamping the venous line while flowing the fluid through the circuit to build up pressure in the circuit.

20. The method of claim 15, wherein each of the arterial line, the venous line, and the line to the waste container is equipped with a clamp, and two of the clamps are mechanically linked so that their operation is mutually exclusive such that when one of the two clamps is open, the other of the two clamps is closed.

21. A hemodialysis system configured to be automatically primed, comprising:

a prime fluid source container;

a waste prime fluid container;

an extracorporeal circuit including a venous line, an arterial line and a chamber including a filter that allows air to escape from the chamber, wherein a liquid entry port and a liquid exit port are in a bottom region of the chamber, and the filter is in a top region of the chamber, and the prime fluid source container is in fluid communication with the arterial line;

a three way connector connecting the venous line, the arterial line and a waste prime fluid container;

a clamping system configured to clamp the arterial line or a connection to the waste prime fluid container closed; and

a level detector configured to detect a level of liquid in the chamber for determining whether the extracorporeal circuit has been sufficiently primed.

22. The system of claim 21, further comprising:

a reversible pump for pumping fluid through the circuit; and

a controller configured to control the pump and to control the clamping system.

23. The system of claim 21, wherein the clamping system includes a two way clamp configured to alternatively clamp the arterial line or the connection to the waste prime fluid container closed.

24. The system of claim 21, wherein the clamping mechanism includes a plurality of valves.

25. The system of claim 21, wherein the clamping mechanism includes a clamp.

26. The system of claim 21, further comprising:

a holder for supporting the extracorporeal circuit; and

a dialyzer, wherein the dialyzer is non-rotatably secured to the holder.

27. The system of claim 21, wherein the filter is a hydrophobic microporous filter.

28. A computer program product, encoded on a computer-readable medium, operable to cause data processing apparatus to perform operations that control a hemodialysis machine comprising:

receiving instructions to initiate a priming sequence;

in response to receiving the instructions, sending instructions to a clamping mechanism to cause the clamping mechanism to occlude a connection between a tube to a prime container and a first patient line;

after the first patient line is occluded, sending instructions to a pump to cause the pump to run in a first direction to circulate fluid through a circuit for a first pumping time;

determining when the first pumping time has elapsed;

after determining that the first pumping time has elapsed, sending instructions to the clamping mechanism to open the first patient line, to cause the tube to the prime container to be occluded and to cause a second patient line to be no longer in fluid connection with the prime container and to only be in fluid connection with the first patient line;

after the first patient line is connected to the second patient line, sending instructions to the pump to cause the pump to run in reverse;

sending instructions to a level detector to detect a level of liquid in a vented chamber of the circuit, wherein a liquid entry port and a liquid exit port are in a bottom region of the chamber, and a filter is in a top region of the chamber; and

sending instructions to indicate that the priming sequence is complete upon receiving signals indicating that the level of liquid in the vented chamber has reached a desired level.

29. The computer program product of claim 28, wherein the clamping mechanism includes a plurality of valves.

30. The computer program product of claim 28, wherein the clamping mechanism includes a clamp.

31. The computer program product of claim 28, further comprising causing the data processing apparatus to perform operations comprising determining a pump reversal time, wherein sending instructions to the pump to cause the pump to run in reverse occurs at the pump reversal time.

32. The computer program product of claim 28, wherein determining a pump reversal time comprises receiving an actual flow rate and determining the pump reversal rate from the actual flow rate and a predetermined forward pumping volume.

33. The computer program product of claim 28, further comprising causing the data processing apparatus to perform operations comprising:

receiving instructions to begin pumping fluid from a patient;

in response to receiving the instructions to begin pumping fluid from a patient, sending instructions to the pump to run the pump; and

sending instructions to the clamping mechanism to open a connection between the second patient line and the prime container.

34. The computer program product of claim 33, further comprising causing the data processing apparatus to perform operations comprising:

receiving instructions to stop the pump after opening the connection between the second patient line and the prime container; and

sending instructions to the pump to stop the pump in response to the instructions to stop the pump.