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Methods to mobilize progenitor/stem cells

DC CAFC
  • US 7,897,590 B2
  • Filed: 08/20/2007
  • Issued: 03/01/2011
  • Est. Priority Date: 07/31/2001
  • Status: Active Grant
First Claim
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1. A method to obtain progenitor and/or stem cells from a subject which method comprises:

  • (a) administering to said subject a compound of the formula
    Z-linker-Z′





    (1)or a pharmaceutically acceptable salt thereofwherein Z is a cyclic polyamine containing 9-32 ring members of which 2-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system;

    or Z is of the formula

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