Composite spectral measurement method and its spectral detection instrument

• US 7,899,506 B2
• Filed: 09/25/2003
• Issued: 03/01/2011
• Est. Priority Date: 11/04/2002
• Status: Active Grant

• Current Assignee: Tianjin Sunrise Technologies Development Co., Ltd.
• Original Assignee: Tianjin Sunshine Optics Technologies Co., Ltd.
• Inventors: Wang, Renda, Ma, Yiwen, Xu, Kexin
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US10/532,669
• Publication Number:
  US 20060167347A1
• Time in Patent Office: 2,714 Days
• Field of Search: 600309-344
• US Class Current: 600/316
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: G01J 3/10 Arrangements of light sources specially adapted for spectrometry or colorimetry
• CPC Class Codes: G01J 3/1256 using acousto-optic tunable filter; acousto-optic elements or systems G02F1/11, G02F1/33
• CPC Class Codes: G01N 2021/3144 for oxymetry
• CPC Class Codes: G01N 21/359 using near infrared light

Abstract

The present invention discloses a spectral measurement method via continuous light source and discrete light source, and a measurement instrument for non-invasive detection of human body tissue components. Said instrument includes an incident unit, a probe, a receiving unit and a data processing unit. Said composite spectral measurement method improves or strengthens the output light intensity at the wavelength that carries information of the target component within human body. It enables the spectral detection in the whole wavelength range, and thus significantly enhances the SNR of the detecting system. In the non-invasive detection instrument, light from both the continuous light source and discrete light source can be firstly selectively light-split by AOTF, or AOTF conducts light-splitting for the continuous light source, while the discrete light source LD is controlled by a spatial chopper. When data of the spectral curves achieved from said continuous light source and discrete light source are processed, data acquired under different measuring modes can be compared.

Claims

1. A composite spectral measurement method comprising:

emitting a composite light from an incident light source composed of a continuous light source and a discrete light source, the continuous light source emitting wideband continuous light, the discrete light source emitting at least one single-wavelength light or at least one narrowband continuous light, wherein the wavelength of the at least one single-wavelength light or the spectrum of the narrowband continuous light is within a range of the spectrum of the wideband continuous light;

using a probe, irradiating the composite light onto a target position, and receiving light reflected by the target position at the probe, wherein the wideband continuous light and the at least one single-wavelength light or at least one narrowband continuous light are irradiated onto the target position through an exiting position in the probe, and the light reflected by the target position is received at a receiving position;

in a receiving unit, adding the wideband continuous light reflected by the target position and the at least one single-wavelength light or at least one narrowband continuous light reflected by the target position in an overlapped or non-overlapped manner, to obtain a composite spectrum; and

in a data processing unit, analyzing the obtained composite spectrum by using a mathematical model to obtain a concentration of a component of interest.

2. The composite spectral measurement method according to claim 1, wherein the wideband continuous light and the at least one single-wavelength light or at least one narrowband continuous light are irradiated onto the target position respectively through different exiting positions in the probe, and the light reflected by the target position is received at a plurality of receiving positions.

3. The composite spectral measurement method according to claim 1, wherein the continuous light source is an acoustic optical tunable filter NIR spectrometer;

and

the discrete light source is a light emitting diode (LED), or a laser diode (LD), or a tunable semiconductor laser.

4. The composite spectral measurement method according to claim 3, wherein the discrete light source is composed of one or more laser diodes (LDs).

5. The composite spectral measurement method according to claim 1, wherein the range of the spectrum of the wideband continuous light is any wavelength band within 0.8-2.5 μ

m.

6. The composite spectral measurement method according to claim 5, wherein the wavelength of the at least one single-wavelength light is one of 980 nm, 1310 nm, 1550 nm, 1610 nm and 1650 nm.

7. The composite spectral measurement method according to claim 6, wherein the component of interest is blood glucose.

8. The composite spectral measurement method according to claim 1, wherein in the receiving unit, the wideband continuous light reflected by the target position and the at least one single-wavelength light or at least one narrowband continuous light reflected by the target position are measured by a sampling sequential control, in which the sampling sequential control comprises one of:

measuring the wideband continuous light reflected by the target position first, and then measuring the at least one single-wavelength light or at least one narrowband continuous light reflected by the target position;

or

measuring the at least one single-wavelength light or at least one narrowband continuous light reflected by the target position first, and then measuring the wideband continuous light reflected by the target position;

or

according to a sequence of wavelength, alternatively measuring the wideband continuous light reflected by the target position and the at least one single-wavelength light or at least one narrowband continuous light reflected by the target position.

9. A non-invasive composite spectral detection instrument comprising:

an incident light source composed of a continuous light source and a discrete light source for emitting a composite light, the continuous light source emitting wideband continuous light, the discrete light source emitting at least one single-wavelength light or at least one narrowband continuous light, wherein the wavelength of the at least one single-wavelength light or the spectrum of the narrowband continuous light is within a range of the spectrum of the wideband continuous light;

a continuous light transmission fiber for transmitting the wideband continuous light emitted from the continuous light source;

a discrete light transmission fiber for transmitting the at least one single-wavelength light or at least one narrowband continuous light emitted from the discrete light source;

a probe for irradiating the composite light onto a target position, and for receiving light reflected by the target position;

a receiving fiber for transmitting the light reflected by the target position and received by the probe;

a receiving unit for adding the wideband continuous light reflected by the target position and the at least one single-wavelength light or at least one narrowband continuous light reflected by the target position in a overlapped or non-overlapped manner, to obtain a composite spectrum; and

a data processing unit for analyzing the obtained composite spectrum by using a mathematical model to obtain a concentration of a component of interest.

10. The non-invasive composite spectral detection instrument according to claim 9, wherein a light exiting end of the continuous light transmission fiber is of a ring shape, a light exiting end of the discrete light transmission fiber is of a circle shape, a light incident end of the receiving fiber is of a ring shape, an end of the probe is of a circle shape,

the light exiting end of the continuous light transmission fiber, the light exiting end of the discrete light transmission fiber and the light incident end of the receiving fiber are concentrically arranged with a center at the center of the end of the probe,

the light exiting end of the discrete light transmission fiber is located at the center of the end of the probe,

the light exiting end of the continuous light transmission fiber is immediately adjacent to the light exiting end of the discrete light transmission fiber, and

the light incident end of the receiving fiber is outside of the light exiting end of the continuous light transmission fiber.

11. The non-invasive composite spectral detection instrument according to claim 9, wherein the receiving fiber comprises an inner receiving fiber and an outer receiving fiber,

a light exiting end of the continuous light transmission fiber is of a ring shape, a light exiting end of the discrete light transmission fiber is of a circle shape, a light incident end of the inner receiving fiber and a light incident end of the outer receiving fiber are both of a ring shape, an end of the probe is of a circle shape,

the light exiting end of the continuous light transmission fiber, the light exiting end of the discrete light transmission fiber, the light incident end of the inner receiving fiber and the light incident end of the outer receiving fiber are concentrically arranged with a center at the center of the end of the probe,

the light exiting end of the discrete light transmission fiber is located at the center of the end of the probe,

the light incident end of the inner receiving fiber is outside of the light exiting end of the discrete light transmission fiber,

the light exiting end of the continuous light transmission fiber is outside of the light incident end of the inner receiving fiber, and

the light incident end of the outer receiving fiber is outside of the light exiting end of the continuous light transmission fiber.

12. The non-invasive composite spectral detection instrument according to claim 9, wherein the continuous light source is an acoustic optical tunable filter NIR spectrometer;

and

the discrete light source is a light emitting diode (LED), or a laser diode (LD), or a tunable semiconductor laser.

13. The non-invasive composite spectral detection instrument according to claim 12, wherein the discrete light source is composed of one or more laser diodes (LDs).

14. The non-invasive composite spectral detection instrument according to claim 9, wherein the continuous light source emits the wideband continuous light whose spectrum has a range of any wavelength band within 0.8-2.5 μ

m.

15. The non-invasive composite spectral detection instrument according to claim 14, wherein the discrete light source emits the at least one single-wavelength light at a wavelength of one of 980 nm, 1310 nm, 1550 nm, 1610 nm and 1650 nm.

16. The non-invasive composite spectral detection instrument according to claim 15, wherein the component of interest is blood glucose.

17. The non-invasive composite spectral detection instrument according to claim 9, wherein the receiving unit measures the wideband continuous light reflected by the target position and the at least one single-wavelength light or at least one narrowband continuous light reflected by the target position using a sequential sampling control, in which the sequential sampling control is adapted to perform one of:

measuring the wideband continuous light reflected by the target position first, and then measuring the at least one single-wavelength light or at least one narrowband continuous light reflected by the target position;

or

measuring the at least one single-wavelength light or at least one narrowband continuous light reflected by the target position first, and then measuring the wideband continuous light reflected by the target position;

or

according to a sequence of wavelength, alternatively measuring the wideband continuous light reflected by the target position and the at least one single-wavelength light or at least one narrowband continuous light reflected by the target position.