Low oxygen in vivo analyte sensor

  • US 7,899,511 B2
  • Filed: 01/17/2006
  • Issued: 03/01/2011
  • Est. Priority Date: 03/04/1997
  • Status: Expired due to Term
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1. A glucose sensor system comprising:

  • an electrode configured to measure a concentration of glucose in a host, wherein the electrode comprises an exposed electroactive surface with an area of from about 0.000084 cm2 to about 0.016 cm2;

    a membrane disposed over the electrode and configured to limit transport of glucose to the electrode; and

    sensor electronics operably connected to the electrode and configured to measure a current flow associated with the electrode, wherein the sensor electronics are configured to measure the current flow in at least a picoAmp range;

    wherein the system is configured to have a glucose sensitivity of from about 1 pA/mg/dL to about 25 pA/mg/dL, and wherein the system is configured to measure the current flow associated with the electrode with substantial linearity at glucose concentrations of up to about 400 mg/dL in a fluid with an oxygen concentration of less than about 0.6 mg/L.

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