Drive mechanisms suitable for use in drug delivery devices

• US 7,918,832 B2
• Filed: 04/08/2004
• Issued: 04/05/2011
• Est. Priority Date: 04/10/2003
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Dca Design International Ltd.
• Inventors: Jones, Christopher John, Veasey, Robert Frederick
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Stigell; Theodore J
• Application Number:
  US10/820,047
• Publication Number:
  US 20050004529A1
• Time in Patent Office: 2,553 Days
• Field of Search: 604207-211, 604/187, 604/189
• US Class Current: 604/207
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31575 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button

Abstract

A drive mechanism for use in a drug delivery device comprising an epicyclic gearbox. This drive mechanism includes a housing having a helical thread; a piston rod having a non-circular cross section and an external helical thread; a dose dial sleeve, which is threadedly engaged with the housing and being rotatable with respect to the housing; and a drive sleeve, located between the housing and the piston rod, which is threadedly engaged with the piston rod.

Claims

1. A drive mechanism for a drug delivery device comprising:

an epicyclic gearbox;

a piston rod including a non-circular cross-section and an external helical thread; and

a drive sleeve configured to engage with the external helical thread of the piston rod;

wherein the drive sleeve is configured to be disposed between a housing and the piston rod.

2. The drive mechanism of claim 1, wherein the drive sleeve is configured to be releasibly connected to a dose dial sleeve via the epicyclic gearbox.

3. An assembly for use in a drug delivery device, comprising:

a drive mechanism including an epicyclic gearbox, a piston rod including a non-circular cross-section and an external helical thread, and a drive sleeve configured to engage with the external helical thread of the piston rod;

a housing including a helical thread; and

a dose dial sleeve configured to engage with the helical thread of the housing and configured to rotate relative to the housing;

wherein the drive sleeve is configured to be disposed between the housing and the piston rod.

4. The assembly of claim 3, wherein the dose dial sleeve is configured to be releasibly connected to the drive sleeve via the epicyclic gearbox.

5. A drug delivery device, comprising:

a drive mechanism including an epicyclic gearbox, a piston rod including a non-circular cross-section and an external helical thread, a drive sleeve configured to engage with the external helical thread of the piston rod;

a housing including a helical thread, a portion of the housing configured to receive a medicinal product to be delivered; and

a dose dial sleeve configured to engage with the helical thread of the housing and configured to rotate relative to the housing;

wherein the drive sleeve is configured to be disposed between the housing and the piston rod.

6. The drug delivery device of claim 5, wherein the dose dial sleeve is configured to be releasibly connected to the drive sleeve via the epicyclic gearbox.

7. A method of assembling a drug delivery device, comprising:

providing a drive mechanism including an epicyclic gearbox, a piston rod including a non-circular cross-section and an external helical thread, and a drive sleeve;

providing a housing including a helical thread;

providing a dose dial sleeve configured to rotate relative to the housing;

engaging the dose dial sleeve with the helical thread of the housing;

placing the drive sleeve between the housing and the piston rod; and

engaging the drive sleeve with the external helical thread of the piston rod.

8. The method of claim 7, further comprising:

releasibly connecting the dose dial sleeve to the drive sleeve via the epicyclic gearbox.

9. A method of assembling a drug injection device, comprising:

providing a housing having a first portion and a second portion, the first portion of the housing being configured to receive a cartridge containing a medicinal product to be dispensed;

providing an assembly including a drive mechanism including an epicyclic gearbox and a piston rod including a non-circular cross-section and an external helical thread in the second portion of the housing.

10. A method of assembling a drug delivery device, comprising:

providing an assembly including a drive mechanism including an epicyclic gearbox, a piston rod including a non-circular cross-section and an external helical thread, and a drive sleeve;

providing a housing including a helical thread;

providing a dose dial sleeve configured to rotate relative to the housing;

engaging the dose dial sleeve with the helical thread of the housing;

placing the drive sleeve between the housing and the piston rod; and

engaging the drive sleeve with the external helical thread of the piston rod.

11. The method of claim 10, further comprising:

releasibly connecting the dose dial sleeve to the drive sleeve via the epicyclic gearbox.

12. A method of dispensing a medicinal product, comprising:

providing a drug delivery device including a drive mechanism including an epicyclic gearbox and a piston rod including an external helical thread; and

dispensing the medicinal product via the drug delivery device;

wherein the medicinal product includes an active ingredient selected from the group consisting of insulin, growth hormone, low molecular weight heparin, analogues of insulin, analogues of growth hormones, analogues of low molecular weight heparin, derivatives of insulin, derivatives of growth hormones, and derivatives of low molecular weight heparin.

13. The method of claim 12, wherein the drive mechanism further includes a drive sleeve configured to engage with the external helical thread of the piston rod;

wherein the drug delivery device further includes a housing including a helical thread; and

a dose dial sleeve configured to engage with the helical thread of the housing and configured to rotate relative to the housing;

wherein the drive sleeve is disposed between the housing and the piston rod; and

wherein dispensing the medicinal product further includes selectively rotating the dose dial sleeve relative to the drive sleeve.

14. The method of claim 13, wherein the dose dial sleeve is configured to be releasibly connected to the drive sleeve via the epicyclic gearbox.

15. The method of claim 12, wherein the piston rod further includes a non-circular cross-section.