Ischemia detection using a heart sound sensor

• US 7,922,669 B2
• Filed: 06/08/2005
• Issued: 04/12/2011
• Est. Priority Date: 06/08/2005
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Dalal, Yousufali, Haro, Carlos, Zhang, Yi, Siejko, Krzysztof Z., Fogoros, Richard, Brockway, Marina
• Primary Examiner(s): Bertram; Eric D
• Application Number:
  US11/148,107
• Publication Number:
  US 20060282000A1
• Time in Patent Office: 2,134 Days
• Field of Search: 600/528
• US Class Current: 600/528
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 7/04 Electric stethoscopes microphones, acoustic transducers therefor H04R
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation

Abstract

A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient'"'"'s heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

Claims

1. A system comprising:

an implantable medical device (IMD) comprising;

an implantable heart sound sensor operable to produce an electrical signal representative of at least one heart sound, the heart sound associated with mechanical activity of a patient'"'"'s heart;

a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal; and

a signal analyzer circuit coupled to the heart sound sensor interface circuit, wherein the signal analyzer circuit is configured to;

measure a baseline value of a characteristic of at least one of an S3 or S4 heart sound in the heart sound signal;

deem that an ischemic event occurred using a measured subsequent change in the heart sound characteristic from the established baseline value of the characteristic; and

discriminate a transient ischemic event from an acute myocardial infarction using the measured subsequent change in the heart sound signal from the established baseline heart sound signal.

2. The system of claim 1, wherein the characteristic of the at least one of the S3 or S4 heart sound is selected from the group consisting of:

an amplitude of the heart sound;

a power spectrum of the heart sound;

an amplitude of the heart sound normalized with respect to an amplitude of a second heart sound;

an amplitude of the heart sound normalized with respect to a measured power of the heart sound signal measured during systole;

a frequency of occurrence of the heart sound in the heart sound signal; and

a duration of an occurrence of the heart sound in the heart sound signal.

3. The system of claim 1, further including a memory circuit coupled to the signal analyzer circuit, the memory circuit to store a segment of a sampled heart sound signal, the segment including the heart sound signal sampled before the change in the heart sound signal, and to store the heart sound signal sampled after the change in the heart sound signal.

4. The system of claim 1, wherein the IMD includes a posture sensor and the IMD is operable to measure a heart sound signal in association with a posture of a patient.

5. The system of claim 1, wherein the IMD includes an activity sensor and the IMD is operable to measure a heart sound signal in association with patient activity.

6. The system of claim 1, the signal analyzer circuit is operable to activate an alarm indicative of a deemed ischemic event.

7. The system of claim 1, wherein the signal analyzer circuit is operable to distinguish between an ischemic event that occurred and a congestive heart failure condition that has worsened by using a time constant of the measured subsequent change from the baseline signal.

8. The system of claim 7, the signal analyzer circuit is operable to activate an alarm indicative of a worsening condition of congestive heart failure.

9. The system of claim 1, wherein the signal analyzer circuit is operable to calculate trend data of measured subsequent changes from the baseline signal, and wherein the IMD includes a memory circuit to store the trend data.

10. The system of claim 9, wherein the signal analyzer circuit is operable to generate a congestive heart failure status indication using the trend data.

11. The system of claim 9, wherein the IMD includes a communication circuit coupled to the signal analyzer circuit and the IMD is operable to communicate information about the measured subsequent change in the heart sound signal to an external device.

12. The system of claim 11, wherein the external device initiates at least one heart sound measurement.

13. The system of claim 9, including an external device in communication with a computer network and the IMD.

14. The system of claim 1, including at least one implantable cardiac signal sensing circuit coupled to the signal analyzer circuit, the implantable cardiac signal sensing circuit operable to produce an electrical cardiac signal representative of cardiac activity of the patient, and wherein the signal analyzer circuit is further operable to measure a heart sound signal in association with the electrical cardiac activity signal.

15. The system of claim 14, wherein the signal analyzer circuit is further operable to deem an ischemic event occurred in accordance with at least one of a measured change in the electrical cardiac signal from an established baseline electrical cardiac signal and the measured subsequent change in the heart sound signal from the established baseline heart sound signal.

16. The system of claim 14, wherein the signal analyzer circuit is further operable to deem an ischemic event occurred using both a measured change in the electrical cardiac signal from an established baseline electrical cardiac signal and the measured subsequent change in the heart sound signal from the established baseline heart sound signal.

17. The system of claim 14, wherein the signal analyzer circuit initiates at least one heart sound measurement in response to a sensed cardiac signal.

18. The system of claim 14, wherein the signal analyzer is operable to deem an ischemic event occurred using a temporal relationship of a measured change in the cardiac signal from an established baseline cardiac signal and the measured subsequent change in the heart sound signal from the established baseline heart sound signal.

19. A system comprising:

an implantable medical device (IMD) comprising;

an implantable heart sound sensor operable to produce an electrical signal representative of at least one heart sound, the heart sound associated with mechanical activity of a patient'"'"'s heart;

a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal;

at least one implantable cardiac signal sensing circuit operable to produce an electrical cardiac signal representative of cardiac activity of the patient; and

a signal analyzer circuit coupled to the heart sound sensor interface circuit and the cardiac signal sensing circuit, wherein the signal analyzer circuit is configured to;

measure a heart sound signal in association with the electrical cardiac activity signal;

measure a baseline value of a characteristic of at least one of an S3 or S4 heart sound in the heart sound signal;

assign a first weight to the measured subsequent change in the heart sound signal from the established baseline heart sound signal and a second weight to the measured change in the electrical cardiac signal from an established baseline electrical cardiac signal; and

deem that an ischemic event occurred using a measured change in the electrical cardiac signal from an established baseline electrical cardiac signal, a measured subsequent change in the heart sound characteristic from the established baseline value of the characteristic, and the assigned weights.