Methods and systems for analysis of nutraceutical associated components

• US 7,927,787 B2
• Filed: 12/11/2006
• Issued: 04/19/2011
• Est. Priority Date: 06/28/2006
• Status: Expired due to Fees

• Current Assignee: Persephone Biome, Inc.
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Wood, Lowell L. Jr., Lord, Robert W., Levien, Royce A., Jung, Edward K. Y., Malamud, Mark A., Rinaldo, John D. Jr., Leuthardt, Eric C.
• Primary Examiner(s): YANG, NELSON C
• Application Number:
  US11/637,638
• Publication Number:
  US 20080003307A1
• Time in Patent Office: 1,590 Days
• Field of Search: None
• US Class Current: 435/4
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: G01N 33/48 Biological material, e.g. blood, urine G01N33/02, G01N33/26, G01N33/44, G01N33/46 take precedence; Haemocytometers counting blood corpuscules distributed over a surface by scanning the surface G06M11/02

Abstract

The present disclosure relates to methods and systems that may be used for analysis of nutraceutical associated components.

Claims

1. A method comprising:

receiving one or more parameters of an individual including at least one behavioral, characteristic, and/or appearance related parameter;

receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, and/or blood;

assaying using one or more microfluidic chips the two or more samples to detect at least one amount of testosterone of each sample;

determining one or more testosterone amount changes over time using the at least one amount of testosterone of each sample; and

identifying, based upon one or more potential relationships of the one or more testosterone amount changes and the one or more parameters, one or more dosages and/or one or more dosage modifications of one or more non-pharmaceutically regulated nutraceutical agents for supplementation of the individual.

2. The method of claim 1, wherein the receiving one or more parameters of an individual including at least one behavioral, characteristic, and/or appearance related parameter comprises:

receiving via one or more user interfaces one or more parameters of an individual including at least one behavioral, characteristic, and/or appearance related parameter.

3. The method of claim 1, wherein the receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, and/or blood comprises:

receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, blood, sweat, tears, breath, skin, hair, excrement, and/or mucus.

4. The method of claim 1, wherein the receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, and/or blood comprises:

receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one hormone, prohormone, polynucleotide, enzyme, protein, vitamin, mineral, metal, and/or antioxidant.

5. The method of claim 1, wherein the assaying using one or more microfluidic chips the two or more samples to detect at least one amount of testosterone of each sample comprises:

assaying at different times and using one or more microfluidic chips the two or more samples to detect at least one amount of testosterone of each sample.

6. The method of claim 1, wherein the assaying using one or more microfluidic chips the two or more samples to detect at least one amount of testosterone of each sample comprises:

assaying using one or more detection units detachably associatable with one or more microfluidic chips the two or more samples to detect at least one amount of testosterone of each sample.

7. The method of claim 1, wherein one or more operations of the method are performed using one or more hand-held portable devices.

8. The method of claim 1, wherein one or more operations of the method are performed using two or more devices.

9. The method of claim 1, further comprising:

displaying at least one of the one or more dosages and/or one or more dosage modifications.

10. The method of claim 1, further comprising:

displaying at least one of the one or more dosages and/or one or more dosage modifications with one or more operably coupled display units.

11. The method of claim 1, further comprising:

displaying at least one of the one or more dosages and/or one or more dosage modifications in human-readable format.

12. The method of claim 1, further comprising:

displaying at least one of the one or more dosages and/or one or more dosage modifications in machine-readable format.

13. The method of claim 1, further comprising:

displaying one or more amounts and/or concentrations of testosterone.

14. The method of claim 1, further comprising:

transmitting one or more signals.

15. The method of claim 1, further comprising:

transmitting one or more signals to one or more display units.

16. The method of claim 1, further comprising:

transmitting one or more signals to one or more recording units.

17. The method of claim 1, further comprising:

transmitting one or more signals to one or more supplement suppliers.

18. The method of claim 1, further comprising:

receiving one or more signals.

19. The method of claim 1, further comprising:

providing for user interaction.

20. The method of claim 1, further comprising:

determining one or more predictions associated with testosterone.

21. A system comprising:

circuitry programmed to receive one or more parameters of an individual including at least one behavioral, characteristic, and/or appearance related parameter;

circuitry programmed to operate one or more devices for receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, and/or blood;

circuitry programmed to operate one or more microfluidic chips for assaying the two or more samples to detect at least one amount of testosterone of each sample;

circuitry programmed to determine one or more testosterone amount changes over time using the at least one amount of testosterone of each sample; and

circuitry programmed to identify, based upon one or more potential relationships of the one or more testosterone amount changes and the one or more parameters, one or more dosages and/or one or more dosage modifications of one or more non- pharmaceutically regulated nutraceutical agents for supplementation of the individual.

22. The system of claim 21, wherein the circuitry programmed to receive one or more parameters of an individual including at least one behavioral, characteristic, and/or appearance related parameter comprises:

circuitry programmed to receive via one or more user interfaces one or more parameters of an individual including at least one behavioral, characteristic, and/or appearance related parameter.

23. The system of claim 21, wherein the circuitry programmed to operate one or more devices for receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, and/or blood comprises:

circuitry programmed to operate one or more devices for receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, blood, sweat, tears, breath, skin, hair, excrement, and/or mucus.

24. The system of claim 21, wherein the circuitry programmed to operate one or more devices for receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, and/or blood comprises:

circuitry programmed to operate one or more devices for receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one hormone, prohormone, polynucleotide, enzyme, protein, vitamin, mineral, metal, and/or antioxidant.

25. The system of claim 21, wherein the circuitry programmed to operate one or more microfluidic chips for assaying the two or more samples to detect at least one amount of testosterone of each sample comprises:

circuitry programmed to operate one or more microfluidic chips for assaying at different times the two or more samples to detect at least one amount of testosterone of each sample.

26. The system of claim 21, wherein the circuitry programmed to operate one or more microfluidic chips for assaying the two or more samples to detect at least one amount of testosterone of each sample comprises:

circuitry programmed to operate one or more detection units detachably associatable with one or more microfluidic chips for assaying the two or more samples to detect at least one amount of testosterone of each sample.

27. The system of claim 21, wherein one or more circuitry of the system is included in one or more hand-held portable devices.

28. The system of claim 21, wherein one or more circuitry of the system is included in two or more devices.

29. The system of claim 21, further comprising:

circuitry programmed to operate one or more devices for displaying at least one of the one or more dosages and/or one or more dosage modifications.

30. The system of claim 21, further comprising:

circuitry programmed to operate one or more devices for displaying at least one of the one or more dosages and/or one or more dosage modifications with one or more operably coupled display units.

31. The system of claim 21, further comprising:

circuitry programmed to operate one or more devices for displaying at least one of the one or more dosages and/or one or more dosage modifications in human-readable format.

32. The system of claim 21, further comprising:

circuitry programmed to operate one or more devices for displaying at least one of the one or more dosages and/or one or more dosage modifications in machine-readable format.

33. The system of claim 21, further comprising:

circuitry programmed to operate one or more devices for displaying one or more amounts and/or concentrations of testosterone.

34. The system of claim 21, further comprising:

circuitry programmed to operate one or more devices for transmitting one or more signals.

35. The system of claim 21, further comprising:

circuitry programmed to operate one or more devices for transmitting one or more signals to one or more display units.

36. The system of claim 21, further comprising:

circuitry programmed to operate one or more devices for transmitting one or more signals to one or more recording units.

37. The system of claim 21, further comprising:

circuitry programmed to operate one or more devices for transmitting one or more signals to one or more supplement suppliers.

38. The system of claim 21, further comprising:

circuitry programmed to receive one or more signals.

39. The system of claim 21, further comprising:

circuitry programmed to operate one or more devices for providing for user interaction.

40. The system of claim 21, further comprising:

circuitry programmed to determine one or more predictions associated with testosterone.

41. Non-transitory computer readable media embodying device detectable instructions for facilitating operations comprising:

receiving one or more parameters of an individual including at least one behavioral, characteristic, and/or appearance related parameter;

receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, and/or blood;

assaying using one or more microfluidic chips the two or more samples to detect at least one amount of testosterone of each sample;

determining one or more testosterone amount changes over time using the at least one amount of testosterone of each sample; and

identifying, based upon one or more potential relationships of the one or more testosterone amount changes and the one or more parameters, one or more dosages and/or one or more dosage modifications of one or more non-pharmaceutically regulated nutraceutical agents for supplementation of the individual.

42. The device detectable instructions for facilitating operations of claim 41, wherein the receiving one or more parameters of an individual including at least one behavioral, characteristic, and/or appearance related parameter comprises:

receiving via one or more user interfaces one or more parameters of an individual including at least one behavioral, characteristic, and/or appearance related parameter.

43. The device detectable instructions for facilitating operations of claim 41, wherein the receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, and/or blood comprises:

receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, blood, sweat, tears, breath, skin, hair, excrement, and/or mucus.

44. The device detectable instructions for facilitating operations of claim 41, wherein the receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one of urine, saliva, and/or blood comprises:

receiving two or more samples of the individual collected at two or more different times, the two or more samples including at least one hormone, prohormone, polynucleotide, enzyme, protein, vitamin, mineral, metal, and/or antioxidant.

45. The device detectable instructions for facilitating operations of claim 41, wherein the assaying using one or more microfluidic chips the two or more samples to detect at least one amount of testosterone of each sample comprises:

assaying at different times and using one or more microfluidic chips the two or more samples to detect at least one amount of testosterone of each sample.

46. The device detectable instructions for facilitating operations of claim 41, wherein the assaying using one or more microfluidic chips the two or more samples to detect at least one amount of testosterone of each sample comprises:

assaying using one or more detection units detachably associatable with one or more microfluidic chips the two or more samples to detect at least one amount of testosterone of each sample.

47. The device detectable instructions for facilitating operations of claim 41, wherein one or more operations are performed using one or more hand-held portable devices.

48. The device detectable instructions for facilitating operations of claim 41, wherein one or more operations are performed using two or more devices.

49. The device detectable instructions for facilitating operations of claim 41, further comprising:

displaying at least one of the one or more dosages and/or one or more dosage modifications.

50. The device detectable instructions for facilitating operations of claim 41, further comprising:

displaying at least one of the one or more dosages and/or one or more dosage modifications with one or more operably coupled display units.

51. The device detectable instructions for facilitating operations of claim 41, further comprising:

displaying at least one of the one or more dosages and/or one or more dosage modifications in human-readable format.

52. The device detectable instructions for facilitating operations of claim 41, further comprising:

displaying at least one of the one or more dosages and/or one or more dosage modifications in machine-readable format.

53. The device detectable instructions for facilitating operations of claim 41, further comprising:

displaying one or more amounts and/or concentrations of testosterone.

54. The device detectable instructions for facilitating operations of claim 41, further comprising:

transmitting one or more signals.

55. The device detectable instructions for facilitating operations of claim 41, further comprising:

transmitting one or more signals to one or more display units.

56. The device detectable instructions for facilitating operations of claim 41, further comprising:

transmitting one or more signals to one or more recording units.

57. The device detectable instructions for facilitating operations of claim 41, further comprising:

transmitting one or more signals to one or more supplement suppliers.

58. The device detectable instructions for facilitating operations of claim 41, further comprising:

receiving one or more signals.

59. The device detectable instructions for facilitating operations of claim 41, further comprising:

providing for user interaction.

60. The device detectable instructions for facilitating operations of claim 41, further comprising:

determining one or more predictions associated with testosterone.