Gamma camera including a scintillator and an image intensifier

• US 7,928,397 B2
• Filed: 08/22/2008
• Issued: 04/19/2011
• Est. Priority Date: 08/23/2007
• Status: Expired due to Fees

• Current Assignee: Arizona Board of Regents (University of Arizona)
• Original Assignee: Arizona Board of Regents (University of Arizona)
• Inventors: Furenlid, Lars R., Miller, Brian W., Barber, H. Bradford, Barrett, Harrison H.
• Primary Examiner(s): Porta; David P
• Assistant Examiner(s): BRYANT, MICHAEL C
• Application Number:
  US12/197,120
• Publication Number:
  US 20090050811A1
• Time in Patent Office: 970 Days
• Field of Search: 250/361.R, 250/363.04, 250/370.11, 250/362, 250/370.09, 378/4, 600/407
• US Class Current: 250/361.00R
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/508 for non-human patients
• CPC Class Codes: G01T 1/1642 using a scintillation crystal and position sensing photodetector arrays, e.g. ANGER cameras
• CPC Class Codes: G01T 1/1644 using an array of optically separate scintillation elements permitting direct location of scintillations G01T1/1645 takes precedence

Abstract

A gamma-ray or X-ray detection device including a scintillator configured to convert gamma rays or X-rays into optical radiation, an optical image intensifier configured to intensify the optical radiation to generate intensified optical radiation, an optical coupling system configured to guide the intensified optical radiation, and a solid state detector configured to detect the intensified optical radiation to generate an interaction image representing a gamma-ray or X-ray energy emission.

Claims

1. A gamma-ray imaging device, comprising:

a scintillator which converts gamma rays into localized flashes of light;

an image intensifier that collects a substantial fraction of the light from each flash produced by a single gamma-ray photon and produces an amplified flash of light;

an optical system including a video camera to image each amplified flash onto an imaging detector that operates at a frame rate fast enough to allow spatial separation of most of the clusters of pixels that receive light from different gamma-ray interactions in the scintillator; and

a processing unit programmed with instructions, the instructions when executed identify the clusters of pixels on the video camera associated with respective amplified flashes of individual gamma-ray photons and use the data from said cluster of pixels to perform a statistical estimation of a position where the corresponding gamma-ray photon interacted with the scintillator and the energy deposited in the interaction.

2. The gamma-ray detection device according to claim 1, wherein optical radiation of each amplified flash has a wavelength in a range from 100 nm to 1000 nm.

3. The gamma-ray detection device according to claim 1, wherein the scintillator comprises at least one of a columnar scintillator, a scintillation screen, or a monolithic scintillator.

4. The gamma-ray detection device according to claim 1, wherein the optical intensifier comprises:

a photocathode made of at least one of Bialkali Antimonide, Multialkali Antimonide, Gallium-Arsenic-Phosphorus (GaAsP), or Gallium Arsenic (GaAs).

5. The gamma-ray detection device according to claim 4, wherein the optical intensifier further comprises a microchannel plate.

6. The gamma-ray detection device according to claim 1, wherein said processing unit is configured to:

subtract a background image from the interaction image associated with the light from the different gamma-ray interactions;

identify pixels of the interaction image that are above a certain threshold intensity value within a region-of-interest to define a cluster;

calculate a centroid of the cluster; and

generate a mean value of all the pixel that are located within the region-of-interest.

7. The gamma-ray detection device according to claim 1, wherein said processing unit is configured to:

use a maximum-likelihood algorithm to estimate a vertical position, a horizontal position, said energy, and a depth of interaction of the gamma-rays in the scintillator.

8. The gamma-ray detection device according to claim 1, wherein a rear surface of the scintillator and a faceplate of the image intensifier are in direct contact with each other.

9. A system for capturing tomographic imaging data comprising:

a plurality of aperture plates arranged around an inspection area, the plates having at least one pinhole; and

a plurality of gamma-ray detection devices according to claim 1 arranged around the inspection area so that a plurality of respective optical axes of the plurality of gamma-ray detection devices intersect with the inspection area, the plurality of aperture plates arranged between the detection devices and the inspection area,

wherein each of the plurality of gamma-ray detection devices are arranged at a different angle of orientation towards the inspection area.

10. The system for capturing tomographic imaging data according to claim 9, wherein

a distance from a front surface of the gamma-ray detection devices and the corresponding aperture plates is a range of 2 mm to 200 mm.

11. The gamma-ray detection device according to claim 1, wherein the intensifier comprises:

a first image intensifier configured to intensify optical radiation from a first portion of a rear surface of the scintillator to generate first intensified optical radiation;

a second image intensifier configured to intensify optical radiation from a second portion of the rear surface of the scintillator to generate second intensified optical radiation;

a first and second optical coupling system configured to guide the first and second intensified optical radiation, respectively; and

a first and second detector configured to detect the first and second intensified optical radiation and to generate first and second images, respectively, representing respective gamma-ray interactions in the scintillator.

12. The gamma-ray detection apparatus according to claim 11,

wherein the first portion and the second portion of the rear surface of the scintillator are overlapping.

13. The gamma-ray detection apparatus according to claim 11, further comprising:

a lens unit configured to split the optical radiation from the rear surface of the scintillator into optical radiation from a first portion and a second portion of the rear surface of the scintillator, respectively.

15. The method according to claim 10, wherein said identifying further comprises:

filtering digital data of the imaged amplified flashes to remove noise by a median filter; and

identifying the cluster of pixels by using a thresholding algorithm that is applied to the filtered digital image.

14. A method for gamma-ray imaging, comprising:

in a scintillator, converting gamma rays into localized flashes of light;

collecting a substantial fraction of the light from each flash produced by a single gamma-ray photon and producing an amplified flash of light with an image intensifier;

imaging each amplified flash onto an imaging detector that operates at a frame rate fast enough to allow spatial separation of most of the clusters of pixels that receive light from different gamma-ray interactions in the scintillator; and

identifying the clusters of pixels on the video camera associated with respective amplified flashes of individual gamma-ray photons and using the data from said cluster of pixels to perform a statistical estimation of a position where the corresponding gamma-ray photon interacted with the scintillator and the energy deposited in the interaction.

16. The method according to claim 14, wherein said identifying further comprises:

storing calibration data representing reference clusters generated from a plurality of interaction depths and gamma-ray energies; and

comparing the cluster of pixels of the digital data image with the reference clusters by using a maximum-likelihood algorithm to estimate a horizontal position, a vertical position, a depth, and the energy of the interaction of the gamma-ray in the scintillator.

17. The method according to claim 14, wherein said method further comprises:

calculating a kurtosis value for the cluster of pixels, wherein

said step of processing the digital data image subjects the kurtosis value to the maximum-likelihood estimation.

18. The method according to claim 14, wherein in said step of processing the digital data image by the maximum-likelihood estimation, the maximum-likelihood estimation uses calibration data based on an eccentricity of the cluster.