Resorbable thin membranes
First Claim
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1. A resorbable thin membrane, comprising:
- an amorphous polymer comprising a resorbability greater than 6 months to 24 months and a viscosity property greater than about 1 g/dL to 3.5 g/dL;
a first smooth surface, a second smooth surface, and a thickness extending between the first smooth surface and the second smooth surface;
a glass transition temperature;
a pre-stretch configuration corresponding to a prior state of the membrane in which the thickness was equal to a first thickness;
a post-stretch configuration corresponding to a current state of the membrane in which the thickness is equal to a second thickness which is at least 5 times less than the first thickness, the post-stretch configuration corresponding to the membrane having been previously stretched at the glass transition temperature from the first thickness down to the second thickness;
a propensity, as a consequence of the post-stretch configuration, of the membrane, when brought at a future time to the glass transition temperature, to return to the pre-stretch configuration during which action the thickness increases 5 times above that of the post-stretch configuration from the second thickness to the first thickness; and
the membrane further possessing a characteristic of losing the propensity following the bringing of the membrane at the future time to the glass transition temperature while the membrane is in the post-stretch configuration.
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Abstract
Resorbable lactide polymer thin membranes are disclosed. The thin membranes are constructed of polylactide resorbable polymers, which are engineered to be absorbed into the body relatively slowly over time in order to reduce potential negative side effects. The membranes are formed to have very thin thicknesses, for example, thicknesses between about 0.010 mm and about 0.300 mm. The membranes can be extruded from polylactide polymers having a relatively high viscosity property, can be preshaped with relatively thick portions, and can be stored in sterile packages.
59 Citations
17 Claims
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1. A resorbable thin membrane, comprising:
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an amorphous polymer comprising a resorbability greater than 6 months to 24 months and a viscosity property greater than about 1 g/dL to 3.5 g/dL; a first smooth surface, a second smooth surface, and a thickness extending between the first smooth surface and the second smooth surface; a glass transition temperature; a pre-stretch configuration corresponding to a prior state of the membrane in which the thickness was equal to a first thickness; a post-stretch configuration corresponding to a current state of the membrane in which the thickness is equal to a second thickness which is at least 5 times less than the first thickness, the post-stretch configuration corresponding to the membrane having been previously stretched at the glass transition temperature from the first thickness down to the second thickness; a propensity, as a consequence of the post-stretch configuration, of the membrane, when brought at a future time to the glass transition temperature, to return to the pre-stretch configuration during which action the thickness increases 5 times above that of the post-stretch configuration from the second thickness to the first thickness; and the membrane further possessing a characteristic of losing the propensity following the bringing of the membrane at the future time to the glass transition temperature while the membrane is in the post-stretch configuration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification