Acquiring nerve activity from carotid body and/or sinus

• US 7,953,479 B2
• Filed: 07/09/2010
• Issued: 05/31/2011
• Est. Priority Date: 12/27/2007
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Wenzel, Brian Jeffrey, Farazi, Taraneh Ghaffari
• Primary Examiner(s): Patel; Niketa I
• Assistant Examiner(s): EL-KAISSI, HIBA CARINE
• Application Number:
  US12/833,170
• Publication Number:
  US 20100274219A1
• Time in Patent Office: 326 Days
• Field of Search: 607/9, 607/42, 607/44, 607/45, 607/46, 607/6
• US Class Current: 607/6
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/388 Nerve conduction study, e.g. detecting action potential of peripheral nerves
• CPC Class Codes: A61B 5/4047 afferent nerves, i.e. nerves that relay impulses to the central nervous system
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.

Claims

1. A method comprising:

administering insulin to a patient to lower the patient'"'"'s blood glucose concentration;

acquiring a first electroneurogram of at least a first carotid sinus nerve activity;

based at least in part on the administering and the acquiring, determining a relationship between said patient'"'"'s blood glucose concentration and said patient'"'"'s carotid sinus nerve activity;

wherein determining the relationship comprises filtering the electroneurogram

acquiring a second electroneurogram of at least a second carotid sinus nerve activity;

analyzing the second electroneurogram for at least a decrease in blood glucose concentration using said relationship; and

when there is a decrease in blood glucose concentration, controlling delivery of a therapy, wherein the therapy comprises increasing sympathetic activity.

2. The method of claim 1 wherein the therapy comprises a therapy to treat diabetes.

3. The method of claim 1 wherein filtering the first electroneurogram comprises determining chemosensory information.

4. The method of claim 3 wherein the chemosensory information comprises blood glucose information.

5. The method of claim 1 wherein filtering the first electroneurogram comprises determining barosensory information.

6. One or more non-transitory computer-readable storage media comprising processor executable instructions for performing the acquiring the first and second electroneurograms, the determining, the analyzing, and the controlling of the method of claim 1.

7. The method of claim 1 wherein the increasing sympathetic activity comprises cardiac pacing to increase heart rate.

8. The method of claim 1 further comprising acquiring patient activity information and using the information to, at least in part, control delivery of the therapy.

9. The method of claim 8 wherein the acquiring comprises acquiring information from an accelerometer.

10. The method of claim 1 further comprising assessing a glucometer reading based on the sensing carotid sinus nerve activity indicative of a decrease in blood glucose.

11. The method of claim 1 wherein the increasing sympathetic activity acts to hasten blood glucose release.

12. The method of claim 1 wherein the increasing sympathetic activity acts to hinder insulin release.

13. The method of claim 6 further comprising instructing an insulin pump to alter release of insulin.

14. The method of claim 1 further comprising activating or blocking one or more autonomic nerves related to pancreatic activity.