Methods and compositions for controlled polypeptide synthesis
First Claim
1. A polypeptide composition comprising a block copolypeptide having:
- (a) a total number of overall monomer units that is greater than about 100 amino acid residues; and
(b) a distribution of chain-lengths wherein Mw/Mn of the block copolypeptide is within the range of about 1.01 to about 1.25.
4 Assignments
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Accused Products
Abstract
Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.
7 Citations
17 Claims
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1. A polypeptide composition comprising a block copolypeptide having:
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(a) a total number of overall monomer units that is greater than about 100 amino acid residues; and (b) a distribution of chain-lengths wherein Mw/Mn of the block copolypeptide is within the range of about 1.01 to about 1.25. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification