High performance imaging system for diffuse optical tomography and associated method of use

• US 7,983,740 B2
• Filed: 12/21/2007
• Issued: 07/19/2011
• Est. Priority Date: 12/22/2006
• Status: Active Grant

• Current Assignee: Washington University In St Louis
• Original Assignee: Washington University In St Louis
• Inventors: Perry, Gavin, Zeff, Benjamin, Culver, Joseph
• Primary Examiner(s): JAWORSKI, FRANCIS J
• Application Number:
  US11/962,513
• Publication Number:
  US 20080154126A1
• Time in Patent Office: 1,306 Days
• Field of Search: 600/407, 600473-476, 356432-433, 356/435, 359/238, 359/278, 382/128, 382/131
• US Class Current: 600/476
• CPC Class Codes: A61B 5/0042 for the brain
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence

Abstract

A high performance imaging system for diffuse optical tomography is disclosed. A dense grid utilizing sources, e.g., light emitting diodes (“LEDs”), that achieve high performance at high speed with a high dynamic range and low inter-channel crosstalk are complemented by a system of discrete, isolated receivers, e.g., avalanche photodiodes (“APDs”). The source channels have dedicated reconfigurable encoding control signals, and the detector channels have reconfigurable decoding, allowing maximum flexibility and optimal mixtures of frequency and time encoding and decoding. Each detector channel is analyzed by dedicated, isolated, high-bandwidth receiver circuitry so that no channel gain switching is necessary. The resulting improvements to DOT system performance, e.g., increased dynamic range and decreased crosstalk, enable higher density imaging arrays and provide significantly enhanced DOT image quality. A processor can be utilized to provide sophisticated three dimensional modeling as well as noise reduction.

Claims

1. An imaging system for diffuse optical tomography comprising:

a plurality of light sources, each light source being connected to a separate, isolated digitally controlled power source and being isolated from each other light source;

a plurality of light conduits connected to the plurality of light sources;

an optode grid attachable to a portion of a human subject, wherein the optode grid is connected to the plurality of light conduits;

a plurality of detector channels connected to the optode grid for receiving light from the plurality of light sources after interacting with the human subject;

a plurality of light detectors, each light detector being coupled to only one of the detector channels for instantaneously detecting light received by its coupled channel, each light detector having a separate, isolated power source; and

a plurality of analog to digital converters (ADCs), each ADC connected to only one light detector and converting signals from its connected light detector into a separate digital signals for use in imaging.

2. The imaging system for diffuse optical tomography of claim 1, wherein each digitally controlled power source modulates at a high bandwidth up to 20 megahertz.

3. The imaging system for diffuse optical tomography of claim 1, wherein the plurality of light sources includes a plurality of light emitting diodes.

4. The imaging system for diffuse optical tomography of claim 1, wherein the plurality of light sources is selected from the group consisting of laser diodes, super luminescent emitting diodes, solid state lasers, or other laser sources.

5. The imaging system for diffuse optical tomography of claim 1, wherein the plurality of light conduits includes a plurality of fiber optic cables.

6. The imaging system for diffuse optical tomography of claim 5, wherein at least one of the plurality of fiber optic cables is multi-furcated to receive multiplex light from a single source.

7. The imaging system for diffuse optical tomography of claim 1, wherein each digital input power source is utilized in conjunction with a threshold voltage to minimize crosstalk.

8. The imaging system for diffuse optical tomography of claim 1, wherein the light detectors includes avalanche photo diodes.

9. The imaging system for diffuse optical tomography of claim 1, wherein the light detectors are selected from the group consisting of photodiodes or photomultiplier tubes.

10. The imaging system for diffuse optical tomography of claim 1, wherein the optode grid is a molded component that is attachable to a portion of a human subject with straps.

11. The imaging system for diffuse optical tomography of claim 1, further comprising a processor that generates a model selected from the group consisting of a homogeneous model, a layered model, a sphere model, a hemisphere model, a cylindrically-shaped model, or an anatomically derived model with finite element analysis from the plurality of digital signals.

12. The imaging system for diffuse optical tomography of claim 11, wherein finite element analysis includes finite element, forward light modeling.

13. The imaging system for diffuse optical tomography of claim 1, further includes a processor that utilizes at least one noise reduction algorithm on the plurality of digital signals.

14. The imaging system for diffuse optical tomography of claim 13, wherein said at least one noise reduction algorithm includes linear regression covariance analysis with an increase in contrast-to-noise ratio.

15. The imaging system for diffuse optical tomography of claim 13, wherein the at least one noise reduction algorithms includes independent component analysis.

23. The imaging system for diffuse optical tomography of claim 1, wherein the plurality of light sources are multiplexed in the digital domain.

24. The imaging system for diffuse optical tomography of claim 23, wherein an integrated intensity of the plurality of light sources is controlled by a variable duty cycle for extending the effective dynamic range of the detector.

16. An imaging system for diffuse optical tomography comprising:

a plurality of light emitting diodes, each light emitting diode being connected to a separate, isolated digital input power source and being isolated from each other light emitting diode;

a plurality of fiber optic cables connected in a one-to-one relationship to the plurality of light emitting diodes;

an optode grid attachable to a portion of a human subject, wherein the optode grid is connected to the plurality of fiber optic cables;

a plurality of detector channels connected to the optode grid for receiving light from the plurality of light emitting diodes after interacting with the human subject;

a plurality of avalanche photo diodes, each avalanche photo diode being coupled to only one of the detector channels for detecting light received by its coupled channel, each avalanche photo diode having a separate isolated power source; and

a plurality of analog to digital converters (ADCs), each ADC connected to only one avalanche photo diode and converting signals from its connected avalanche photo diodes into a separate digital signals for imaging.

17. A method for utilizing an imaging system for diffuse optical tomography comprising:

attaching an optode grid to a portion of a human subject, wherein the optode grid design is connected to the plurality of light conduits that are connected to a plurality of light sources, wherein each light source is electrically connected to a separate, isolated digital input power source, and wherein each light source has a separate digital control input for individual programming;

utilizing a plurality of light detectors that are connected to the optode grid via a plurality of detector channels for instantaneously detecting light received at the detector channels, said received light provided by the plurality of light sources after interacting with the human subject, wherein each light detector is coupled to only one of the detector channels, and wherein each light detector has a separate, isolated power source; and

converting a plurality of individual signals from the plurality of light detectors into a plurality of digital signals for imaging with a plurality of analog to digital converters (ADCs), wherein each ADC connects to only one light detector, and wherein each ADC converts signals only from its connected light detector.

18. The method for utilizing an imaging system for diffuse optical tomography according to claim 17, further includes providing signals at a high speed in a high dynamic range to each digital input power source.

19. The method for utilizing an imaging system for diffuse optical tomography according to claim 17, wherein the plurality of light sources is selected from the group consisting of light emitting diodes, laser diodes, super luminescent emitting

diodes, solid state lasers, or other laser sources, and the plurality of discrete, isolated, light detectors is selected from the group consisting of avalanche photo diodes, photodiodes or photomultiplier tubes.

20. The method for utilizing an imaging system for diffuse optical tomography according to claim 17, further includes generating a model selected from the group consisting of a homogeneous model, a layered model, a sphere model, a hemisphere model, a cylindrically-shaped model, or an anatomically derived model with finite element analysis with a processor from the plurality of digital signals.

21. The method for utilizing an imaging system for diffuse optical tomography according to claim 17, further includes utilizing at least one noise reduction algorithm with a processor on the plurality of digital signals, wherein the at least one noise reduction algorithm is selected from the group consisting of linear regression covariance analysis and independent component analysis.

22. The method for utilizing an imaging system for diffuse optical tomography according to claim 17, further includes utilizing filters positioned in front of the plurality of light detectors for detecting fluorescing agents in a human body.