Spectroscopy of deeply-scattered light

• US 7,996,069 B2
• Filed: 09/15/2008
• Issued: 08/09/2011
• Est. Priority Date: 06/06/2003
• Status: Active Grant

• Current Assignee: Infraredx Incorporated (Nipro Corporation)
• Original Assignee: Infraredx Incorporated (Nipro Corporation)
• Inventors: DeJesus, Stephen, Zuluaga, Andres
• Primary Examiner(s): Cattungal; Sanjay
• Application Number:
  US12/210,669
• Publication Number:
  US 20090012407A1
• Time in Patent Office: 1,058 Days
• Field of Search: 600309-344, 600473-480, 606 1- 19
• US Class Current: 600/476
• CPC Class Codes: A61B 5/0062 Arrangements for scanning
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: G02B 23/26 using light guides for illumination G02B23/2469

Abstract

A spectroscope includes first and second beam redirectors in optical communication with first and second fibers respectively. The first and second beam redirectors are oriented to illuminate respective first and second areas. The second area is separated from the first area by a separation distance that exceeds the separation distance between the first and second beam redirectors.

Claims

1. An apparatus for identifying vulnerable plaque in a wall of an artery, the apparatus comprising:

a catheter defining a longitudinal axis;

an optical bench disposed for rotation within the catheter;

first and second fibers extending longitudinally, with distal ends disposed on the optical bench;

a first beam redirector disposed on the optical bench and in optical communication with the distal end of the first fiber and pointed for directing a beam from the first fiber along a first direction;

a second beam redirector disposed on the optical bench and axially separated from the first beam redirector;

wherein the second beam redirector is in optical communication with the distal end of the second fiber and pointed such that the second beam redirector is capable of directing a beam from a second direction into the second fiber;

the first and second beam redirectors being pointed relative to one another to define an angle;

wherein

a first line segment parallel to the longitudinal axis extends between the first direction and the second direction;

a second line segment parallel to the longitudinal axis extends between the first direction and the second direction; and

a distance between the second line segment and the longitudinal axis is greater than a distance between the first line segment and the longitudinal axis,

wherein the second line segment is longer than the first line segment; and

wherein the angle is selected to enhance collection by the second fiber of scattered light from a target located at a selected depth behind the arterial wall.

2. The apparatus of claim 1, wherein at least one of the first and second beam-redirectors comprises a mirror.

3. The apparatus of claim 1, wherein at least one of the first and second beam-redirectors comprises a lens system.

4. The apparatus of claim 1, wherein at least one of the first and second beam-redirectors comprises a mirror in optical communication with the lens system.

5. The apparatus of claim 1, wherein at least one of the first and second beam-redirectors comprises a distal portion of the first or second fiber, the distal portion being bent.

6. The apparatus of claim 1, wherein at least one of the first and second beam-redirectors comprises a diffracting element.

7. The apparatus of claim 1,

wherein the angle defined by the first and second beam re-directors is between 0 radians and π

radians; and

wherein the first separation distance is slightly greater than an average fiber diameter but less than 3 millimeters.

8. The apparatus of claim 1,

Wherein the angle defined by the first and second beam re-directors is between π

/2 radians and the smaller of the numerical apertures of the first and second fibers; and

wherein the first separation distance is slightly greater than an average fiber diameter but less than 1.5 millimeters.

9. The apparatus of claim 1,

wherein the angle defined by the first and second beam re-directors is within a 0.5 radian window having a lower bound defined by the greater of the numerical apertures of the first and second fibers;

and

wherein the first separation distance is within a 0.5 millimeter window having a lower bound defined by a distance slightly greater than an average fiber diameter.

10. The apparatus of claim 1,

wherein the angle defined by the first and second beam re-directors is within a 0.1 radian window centered at the sum of the numerical apertures of the first and second fibers;

and

wherein the first separation distance is within a 0.1 millimeter interval having a lower bound that is 0.35 millimeters greater than an average fiber diameter.

11. The apparatus of claim 1,

wherein the angle defined by the first and second beam re-directors is between 0 and π

/2 radians; and

wherein the first separation distance is between 0.25 millimeters and 3 millimeters.

12. The apparatus of claim 1,

wherein the angle defined by the first and second beam re-directors is between 0.12 radians and π

/2 radians; and

wherein the first separation distance is between 0.25 millimeters and 1.5 millimeters.

13. The apparatus of claim 1,

wherein the angle defined by the first and second beam re-directors is between 0.25 and 0.75 radians;

and

wherein the first separation distance is between 0.25 millimeters and 0.75 millimeters.

14. The apparatus of claim 1, wherein at least one of the first and second fibers comprises an optical fiber having a numerical aperture of 0.12 and a core diameter selected from the group consisting of 9 micrometers, 100 micrometers, and 200 micrometers.

15. The apparatus of claim 1, wherein at least one of the first and second fibers comprises an optical fiber having a numerical aperture of 0.22 and a core diameter selected from the group consisting of 100 micrometers or 200 micrometers.

16. The apparatus of claim 1, wherein at least one of the first and second fibers comprises an optical fiber having a numerical aperture of 0.275 and a core diameter of 62.5 micrometers.

17. The apparatus of claim 1, wherein the second fiber ends at a point distal to the first fiber.

18. The apparatus of claim 1, wherein one or both of the first and second redirectors comprises a plastic incorporating a reflective material.

19. An apparatus for detecting light scattered from within a wall of an artery, the apparatus comprising:

a catheter defining a longitudinal axis;

an optical bench disposed for rotation within the catheter;

first and second fibers extending longitudinally with distal ends disposed on the optical bench;

a first beam redirector disposed on the optical bench for causing a first beam emerging from the first fiber to travel along a first direction away from the catheter;

a second beam redirector disposed on the optical bench for causing a second beam traveling along a second direction toward the catheter to enter the second fiber;

wherein a longitudinal distance between the first beam travelling along the first direction and the second beam travelling along the second direction increases with radial distance from the catheter;

wherein the first and second beam redirectors are pointed relative to one another to cause the second fiber to selectively collect re-entrant light.

20. The apparatus of claim 19, wherein at least one of the first beam redirector for causing a beam emerging from the first fiber to travel along a first direction away from the catheter and the second beam redirector for causing a beam traveling along a second direction toward the catheter to enter the second fiber comprises a mirror.

21. The apparatus of claim 19, wherein at least one of the first beam redirector for causing a first beam emerging from the first fiber to travel along a first direction away from the catheter and the second beam redirector for causing a second beam traveling along a second direction toward the catheter to enter the second fiber comprises a lens system.

22. The apparatus of claim 19, wherein at least one of the first beam redirector for causing a first beam emerging from the first fiber to travel along a first direction away from the catheter and the second beam redirector for causing a second beam traveling along a second direction toward the catheter to enter the second fiber comprises a mirror in optical communication with a lens system.

23. The apparatus of claim 19, wherein at least one of the first beam redirector for causing a first beam emerging from the first fiber to travel along a first direction away from the catheter and the second beam redirector for causing a second beam traveling along a second direction toward the catheter to enter the second fiber comprises a bent distal portion.

24. The apparatus of claim 19, wherein at least one of the first beam redirector for causing a first beam emerging from the first fiber to travel along a first direction away from the catheter and the second beam redirector for causing a second beam traveling along a second direction toward the catheter to enter the second fiber comprises a diffracting element.

25. The apparatus of claim 19, further comprising means for rotating the first beam redirector for causing a first beam emerging from the first fiber to travel along a first direction away from the catheter and the second beam redirector for causing a second beam traveling along a second direction toward the catheter to enter the second fiber.

26. The apparatus of claim 19, wherein the second fiber ends at a point distal to the first fiber.

27. The apparatus of claim 19, wherein at least one of the first beam redirector for causing a first beam emerging from the first fiber to travel along a first direction away from the catheter and the second beam redirector for causing a second beam traveling along a second direction toward the catheter to enter the second fiber comprises a plastic incorporating a reflective material.

28. An apparatus for collecting light scattered from within a wall of an artery, the apparatus comprising:

a catheter defining a longitudinal axis;

an optical bench disposed for rotation within the catheter, on which distal ends of a first and second fiber are located;

the first fiber extending longitudinally to a first point;

the second fiber extending longitudinally to a second point distal to the first point;

a first beam redirector disposed on the optical bench and in optical communication with the distal end of the first fiber, configured to redirect light emerging from the first fiber towards a first location on the wall; and

a second beam redirector disposed on the optical bench and in optical communication with the distal end of the second fiber, configured for redirecting light emerging from the second fiber to a second location on the wall, the second location being distal to the first location;

wherein the distance between the first and second locations is greater than the distance between the first and second points.

29. An apparatus for detecting light scattered from within a wall of an artery, the apparatus comprising:

a catheter;

an optical bench disposed for rotation within the catheter;

first and second fibers, distal ends of which are disposed on the optical bench;

a first beam-redirector disposed on the optical bench and in optical communication with the distal end of the first fiber, the first beam-redirector being pointed to illuminate a first area;

a second beam-redirector disposed on the optical bench and in optical communication with the distal end of the second fiber, the second beam-redirector being pointed to collect light from a second area longitudinally separated from the first area by a separation distance that increases with radial distance from the optical bench;

wherein the first and second beam redirectors are pointed relative to one another to cause the second fiber to selectively collect re-entrant light from the second area.