Surface directed cellular attachment
First Claim
Patent Images
1. A hydrogel having an outer surface and a depth, the hydrogel comprising:
- a plurality of first substantially uniform cavities along the outer surface of the hydrogel, each of said first cavities extending to a bottom surface of said first cavity; and
a plurality of second substantially uniform cavities located below at least one of the first cavities, each of said second cavities extending from the bottom surface of the first cavity;
wherein said first cavities are only located on the outer surface of the hydrogel and do not extend throughout the depth of said hydrogel;
wherein said second cavities do not extend throughout the depth of said hydrogel; and
wherein the hydrogel comprises polyvinyl alcohol.
2 Assignments
0 Petitions
Accused Products
Abstract
Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
397 Citations
20 Claims
-
1. A hydrogel having an outer surface and a depth, the hydrogel comprising:
-
a plurality of first substantially uniform cavities along the outer surface of the hydrogel, each of said first cavities extending to a bottom surface of said first cavity; and a plurality of second substantially uniform cavities located below at least one of the first cavities, each of said second cavities extending from the bottom surface of the first cavity; wherein said first cavities are only located on the outer surface of the hydrogel and do not extend throughout the depth of said hydrogel; wherein said second cavities do not extend throughout the depth of said hydrogel; and wherein the hydrogel comprises polyvinyl alcohol. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
-
-
17. A hydrogel having an outer surface and a depth, the hydrogel comprising:
-
a plurality of first substantially uniform cavities along the outer surface of the hydrogel, each of said first cavities extending to a bottom surface of said first cavity; and a plurality of second substantially uniform cavities located below at least one of the first cavities, each of said second cavities extending from the bottom surface of the first cavity; wherein said first cavities are only located along the outer surface of the hydrogel and do not extend throughout the depth of said hydrogel; wherein said second cavities do not extend throughout the depth of said hydrogel; and wherein the hydrogel is a load bearing device that is configured for implantation in a joint. - View Dependent Claims (18, 19, 20)
-
Specification