Sustained release aminopyridine composition

CAFC
  • US 8,007,826 B2
  • Filed: 12/13/2004
  • Issued: 08/30/2011
  • Est. Priority Date: 12/11/2003
  • Status: Active Grant
First Claim
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1. A method for maintaining a therapeutically effective concentration of 4-aminopyridine in order to improve walking in a human with multiple sclerosis in need thereof, said method comprising:

  • orally administering to the human a sustained release composition of 10 milligrams of 4-aminopyridine twice daily for a day; and

    thereafter,maintaining administration of 4-aminopyridine by orally administering to said human a sustained release composition of 10 milligrams of 4-aminopyridine twice daily for a time period of at least two weeks, whereby an in vivo 4-aminopyridine CmaxSS;

    CminSS ratio of 1.0 to 3.5 and a CavSS of 15 ng/ml to 35 ng/ml are obtained in the human.

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