Granule formation

  • US 8,007,830 B2
  • Filed: 02/07/2008
  • Issued: 08/30/2011
  • Est. Priority Date: 10/26/2001
  • Status: Active Grant
First Claim
Patent Images

1. A flowable and dispersible pharmaceutical composition which comprises (i) granules comprising a pharmaceutically acceptable substrate which is spray-dried mannitol agglomerated with a pharmaceutically acceptable binder, and coated with montelukast sodium, and (ii) a pharmaceutically acceptable lubricant;

  • wherein said binder is selected from hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, ethylcellulose and polyvinylpyrrolidone; and

    said granules are formed by coating said substrate with an aqueous solution consisting of montelukast sodium followed by drying.

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