Adenovirus 36 E4 orf 1 gene and protein and their uses
First Claim
1. An isolated protein, Adenovirus-36 E4 orf 1, whose amino acid sequence comprises SEQ ID NO:
- 2.
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Accused Products
Abstract
Expression of the E4 orf 1 gene of Ad-36 alone has been discovered to be responsible for the increased insulin sensitivity observed in Ad-36 infected animals, including increased adipogenesis. Ad-36 E4 orf 1 protein can be used to increase insulin sensitivity and ameliorate diabetes. Additionally, drugs that mimic the action of Ad-36 E4 orf 1 protein could be found. Ad-36 E4 orf 1 could also be used to increase fat cells in lipodystrophy. We have also discovered that Ad-36 infection in human skeletal muscle cells increased differentiation and insulin independent glucose uptake. It is expected that infection with Ad-36 E4 orf 1 gene will also cause these effects.
5 Citations
9 Claims
- 1. An isolated protein, Adenovirus-36 E4 orf 1, whose amino acid sequence comprises SEQ ID NO:
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4. A method of treating or ameliorating one or more symptoms of a disease in a mammalian patient wherein the disease is chosen from the group consisting of lipodystrophy, diabetes, and insulin resistance, said method comprising administering to the patient a therapeutically effective amount of Adenovirus-36 E4 orf 1 protein whose amino acid sequence comprises SEQ ID NO:
- 2, wherein the patient'"'"'s symptoms improve following said administering.
- View Dependent Claims (5, 6, 7, 8, 9)
Specification