SPG stimulation for treating complications of subarachnoid hemorrhage

• US 8,010,189 B2
• Filed: 10/30/2007
• Issued: 08/30/2011
• Est. Priority Date: 02/20/2004
• Status: Active Grant

• Current Assignee: BrainsGate Ltd.
• Original Assignee: BrainsGate Ltd.
• Inventors: Shalev, Alon
• Primary Examiner(s): Getzow; Scott M
• Application Number:
  US11/928,024
• Publication Number:
  US 20080167700A1
• Time in Patent Office: 1,400 Days
• Field of Search: 607/2, 607/3
• US Class Current: 607/3
• CPC Class Codes: A61N 1/0546 Nasal electrodes
• CPC Class Codes: A61N 1/0548 Oral electrodes
• CPC Class Codes: A61N 1/205 for promoting a biological process
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/37229 Shape or location of the implanted or external antenna

Abstract

A method is provided including identifying that a subject has suffered a subarachnoid hemorrhage (SAH), and treating a complication of the SAH by stimulating at least one site of the subject in conjunction with treating the SAH, the site selected from the group consisting of: a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve.

Claims

1. A method comprising:

identifying that a subject has suffered a subarachnoid hemorrhage (SAH); and

treating vasospasm following the SAH by;

applying stimulation to at least one site of the subject, the stimulation selected from the group consisting of;

application of an electrical current, and application of a magnetic field, and the site selected from the group consisting of;

a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve, and

configuring the stimulation to increase cerebral blood flow (CBF) of the subject.

2. The method according to claim 1, wherein the site includes the SPG of the subject, and wherein applying the stimulation to the site comprises stimulating the SPG.

3. The method according to claim 1, wherein applying the stimulation comprises applying the stimulation in conjunction with treating the SAH.

4. The method according to claim 3, wherein treating the SAH includes clipping an aneurysm that caused the SAH, and wherein applying the stimulation to the site comprises applying the stimulation to the site in conjunction with clipping the aneurysm.

5. The method according to claim 3, wherein treating the SAH includes administering a pharmaceutical composition for treating an aneurysm that caused the SAH, and wherein applying the stimulation to the site comprises applying the stimulation to the site in conjunction with administering the pharmaceutical composition.

6. The method according to claim 3, wherein applying the stimulation to the site comprises applying the stimulation to the site prior to treating the SAH.

7. The method according to claim 3, wherein applying the stimulation to the site comprises applying the stimulation to the site while treating the SAH.

8. The method according to claim 3, wherein applying the stimulation to the site comprises applying the stimulation to the site after treating the SAH.

9. The method according to claim 1, wherein applying the stimulation to the site comprises applying the electrical current to the site.

10. The method according to claim 1, wherein applying the stimulation to the site comprises applying the magnetic field to the site.