Parenteral CCI-779 formulations containing cosolvents, an antioxidant, and a surfactant

  • US 8,026,276 B2
  • Filed: 07/25/2003
  • Issued: 09/27/2011
  • Est. Priority Date: 07/30/2002
  • Status: Active Grant
First Claim
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1. A parenteral composition comprising:

  • (i) a first mixture of about 1 to about 25 mg/mL of CCI-779, about 15 to about 60% w/v of dehydrated ethanol, about 0.01 to about 0.1% w/v of d,1-α

    -tocopherol, about 0.001 to about 0.005% w/v of citric acid, and about 15 to about 60% w/v of propylene glycol, and(ii) a second mixture of about 15 to about 60% w/v of polysorbate 80, 15 to 60% w/v of polyethylene glycol 400, and about 15 to about 60% w/v of dehydrated ethanol.

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