Method of enhancing hair growth

• US 8,038,988 B2
• Filed: 11/21/2007
• Issued: 10/18/2011
• Est. Priority Date: 02/04/2002
• Status: Expired due to Term

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: VanDenburgh, Amanda M., Woodward, David F.
• Primary Examiner(s): Hartley; Michael G
• Assistant Examiner(s): DICKINSON, PAUL W
• Application Number:
  US11/943,714
• Publication Number:
  US 20080070988A1
• Time in Patent Office: 1,427 Days
• Field of Search: None
• US Class Current: 424/70.1
• CPC Class Codes: A61K 2800/10 General cosmetic use
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/557 Eicosanoids, e.g. leukotrienes or prostaglandins
• CPC Class Codes: A61K 31/558 having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/06 Emulsions
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth
• CPC Class Codes: A61Q 7/02 Preparations for inhibiting or slowing hair growth

Abstract

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I

wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R₁ and R₂ are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal. Bimatoprost is preferred for this treatment.

Claims

1. A method of increasing one or more of:

length, thickness, number, density, luster, sheen, brilliance, gloss, glow, shine and patina of eyelash hair in a human, comprising administering an effective amount of bimatoprost to an eyelid margin of a human.

2. The method of claim 1 wherein the effective amount of bimatoprost is administered in the form of a liquid composition containing about 0.03% bimatoprost by weight of the composition.

3. The method of claim 1 wherein bimatoprost is administered to an eyelid margin at least once a day.

4. The method of claim 1 further including a method of increasing one or more of:

length, thickness, number, density, luster, sheen, brilliance, gloss, glow, shine and patina of eyebrow hair in a human, comprising administering an effective amount of bimatoprost to the eyebrow of the human.

5. The method of claim 4 wherein the effective amount of bimatoprost is administered in the form of a liquid composition containing about 0.03% by weight of the composition.

6. The method of claim 2 wherein the composition is a solution.

10. The method of claim 1 wherein the effective amount is administered in the form of a liquid composition containing about 0.001% to about 0.1% bimatoprost by weight of the composition.

11. The method of claim 1 wherein the human is suffering from eyelass loss.

7. A method of increasing one or more of:

length, thickness, number, density, luster, sheen, brilliance, gloss, glow, shine and patina, of hair on a human scalp, comprising administering an effective amount of bimatoprost to the human scalp.

8. The method of claim 7 wherein the effective amount of bimatoprost is administered in the form of a liquid composition containing about 0.001% to about 0.1% bimatoprost by weight of the composition.

9. The method of claim 8 wherein the effective amount of bimatoprost is administered in the form of a liquid composition containing about 0.03% bimatoprost by weight of the composition.

12. The method of claim 7 wherein the human is suffering from hair loss.

13. The method of claim 12 wherein the hair loss is due to alopecia.