Methods for forming biodegradable nanocomponents with controlled shapes and sizes via electrified jetting

• US 8,043,480 B2
• Filed: 10/24/2008
• Issued: 10/25/2011
• Est. Priority Date: 11/10/2004
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Bhaskar, Srijanani, Lahann, Joerg
• Primary Examiner(s): Mayes; Melvin
• Assistant Examiner(s): Qian; Yun
• Application Number:
  US12/257,945
• Publication Number:
  US 20100038830A1
• Time in Patent Office: 1,096 Days
• Field of Search: None
• US Class Current: 204/164
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C08J 2367/04 Polyesters derived from hydroxy carboxylic acids, e.g. lactones C08J2367/06 takes precedence
• CPC Class Codes: C08J 3/122 Pulverisation by spraying
• CPC Class Codes: C08J 3/205 in the presence of a continuous liquid phase
• CPC Class Codes: C09K 11/08 containing inorganic luminescent materials
• CPC Class Codes: D01D 5/0069 characterised by the spinning section, e.g. capillary tube, protrusion or pin
• CPC Class Codes: D01D 5/32 Side-by-side structure; Spinnerette packs therefor
• CPC Class Codes: D01F 8/00 Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
• CPC Class Codes: Y10S 977/906 Drug delivery

Abstract

Methods of forming a plurality multiphasic nano-components (MPNs) having at least two phases, with high selectivity for at least one of shape, size, or phase orientation in the nano-component are provided. The methods provide high yields of substantially similar nano-components by controlling one or more of: polymer concentration, liquid stream composition, liquid stream conductivity, flow rate, humidity, temperature, pressure, electrode design and/or configuration during an electrified jetting process. Such methods of making MPNs form shapes including disks, rods, spheres, rectangles, polygons, toroids, cones, pyramids, cylinders, fibers, and combinations thereof. Such MPNs can be used in various applications, including for medical diagnostics or with pharmaceutical, personal care, oral care, and/or nutritional compositions.

Claims

1. A method of making a multiphasic nano-component comprising:

forming a plurality of nano-components having a high shape selectivity for a shape selected from the group consisting of;

discs, rods, spheres, toroids, and combinations thereof, by jetting two or more liquid streams together and passing them through an electric field generated by electrodes sufficient to form a cone jet that is fragmented to form said plurality of nano-components, each respectively having a first phase and at least one additional phase distinct from said first phase, wherein each of said first phase and said at least one additional phase respectively defines an exposed surface and wherein at least one of said phases comprises a polyester polymer, wherein said forming includes controlling one or more of;

concentration of said polymer in said liquid streams, flow rate of liquid streams, humidity, temperature, design of said electrodes, and configuration of said electrodes during said jetting.

2. The method of claim 1, wherein said polyester polymer is selected from the group consisting of polylactides, polyglycolides, co-polymers, derivatives, and combinations thereof.

3. The method of claim 1, wherein said polymer comprises a poly(lactic co-glycolide) polymer.

4. The method of claim 3, wherein said shape is a rod and a flow rate of the liquid stream is controlled to be greater than or equal to about 0.4 milliliters per hour and less than or equal to about 0.7 milliliters per hour and a concentration of said poly(lactic co-glycolide) polymer in said jetting liquid is about 3 to about 4 weight % of the total jetting liquid.

5. The method of claim 3, wherein said shape is a sphere and a flow rate of the liquid stream is controlled to be less than or equal to about 0.2 milliliters per hour and a concentration of said poly(lactic co-glycolide) polymer in said jetting liquid is greater than about 4 weight % of the total jetting liquid.

6. The method of claim 3, wherein said shape is a disc and a flow rate of the liquid stream is controlled to be less than or equal to about 0.2 milliliters per hour and a concentration of said poly(lactic co-glycolide) polymer in said jetting liquid is about 0.5 to about 2 weight % of the total jetting liquid.

7. The method of claim 3, wherein said poly(lactic co-glycolide) polymer has a ratio of lactic acid monomer to glycolic acid monomer ranging from about 15:

85 to about 85;

15.

8. The method of claim 1, wherein said polymer is present in each said liquid stream at about 0.5 weight % to about 20 weight % of the total liquid stream.

9. The method of claim 1, wherein said high shape selectivity corresponds to forming at least about 50% of said plurality of nano-components having substantially the same shape.

10. The method of claim 1, wherein said high shape selectivity corresponds to forming at least about 70% of said plurality of nano-components having substantially the same shape.

11. The method of claim 1, wherein said first phase comprises a first active ingredient and said at least one additional phase comprises a second active ingredient.

12. The method of claim 1, wherein said first phase and/or said at least one additional phase comprises a pharmaceutically and/or cosmetically active ingredient.

13. A method of making a multiphasic nano-component comprising:

forming a plurality of nano-components by jetting two or more liquid streams together and passing them through an electric field generated by electrodes sufficient to form a cone jet that is fregmented to form said plurality of nano-components, each respective nano-component having a first phase and at least one additional phase distinct from said first phase, wherein each of said first phase and said at least one additional phase respectively defines an exposed surface and wherein at least one of said phases comprises a polymer and said forming of said plurality of nano-components includes controlling one or more of;

concentration of said polymer in said liquid streams, flow rate of said liquid streams, humidity, temperature, design of said electrodes, and configuration of said electrodes during said jetting to form at least about 50% of the plurality of nano-components having substantially the same shape, size, and/or orientation of said first phase or said at least one additional phase.

14. The method of claim 13, wherein said polymer is a polyester polymer selected from the group consisting of polylactides, polyglycolides, co-polymers, derivatives, and combinations thereof.

15. The method of claim 13, wherein said polymer is selected from the group consisting of polylactic acid, polycaprolactone, polyglycolic acid, poly(lactide-co-glycolide polymer (PLGA), and copolymers, derivatives, and combinations thereof.

16. The method of claim 13, wherein said high selectivity corresponds to forming at least about 70% of said plurality of nano-components having substantially the same shape, size, and/or orientation of said first phase or said at least one additional phase.

17. The method of claim 13, wherein said high selectivity corresponds to forming at least about 80% of said plurality of nano-components having substantially the same shape, size, and/or orientation of said first phase or said at least one additional phase.

18. A method of making a multiphasic nano-component comprising:

forming a plurality of nano-components by jetting two or more liquid streams together and passing them through an electric field generated by electrodes sufficient to form a cone jet that is fragmented to form said plurality of nano-components, each respective nano-component having a first phase and at least one additional phase distinct from said first phase, wherein each of said first phase and said at least one additional phase respectively defines an exposed surface and wherein at least one of said phases comprises a polymer selected from the group consisting of polylactides, polyglycolides, co-polymers, derivatives, and combinations thereof;

wherein said forming of said plurality of nano-components includes controlling one or more of;

concentration of said polymer in said liquid streams, flow rate of said liquid streams, humidity, temperature, design of said electrodes, and configuration of said electrodes during said jetting to form at least about 70% of the plurality of nano-components having substantially the same shape.