Method and device for the removal of partially protein bound substances

• US 8,048,310 B2
• Filed: 12/22/2010
• Issued: 11/01/2011
• Est. Priority Date: 03/27/2002
• Status: Expired due to Fees

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Sternby, Berit, Sternby, Jan
• Primary Examiner(s): Kim; John
• Application Number:
  US12/976,653
• Publication Number:
  US 20110089112A1
• Time in Patent Office: 314 Days
• Field of Search: 210/636, 210/645, 210/646, 210/650, 210/651, 210/805, 210/167.01, 210/167.06, 210/175, 210/177, 210/185, 210/194, 210/195.2, 210/203, 210/199, 210/252, 210/253, 210/257.2, 210/258, 210/295, 210/321.6, 210/321.69, 210/321.72, 210/323.1, 210/340, 210/428, 604/4.01, 604/5.04, 604/6.01, 604/6.04, 604/6.09, 604/6.11, 604/28
• US Class Current: 210/650
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1607 before use, i.e. upstream of dialyser
• CPC Class Codes: A61M 1/1633 with more than one dialyser unit
• CPC Class Codes: A61M 1/1647 with flow rate measurement of the dialysis fluid, upstream and downstream of the dialyser
• CPC Class Codes: A61M 1/165 with a dialyser bypass on the dialysis fluid line
• CPC Class Codes: A61M 1/1692 Detection of blood traces in dialysate
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/341 by measuring the filtrate rate or volume
• CPC Class Codes: A61M 1/3431 upstream of the filter
• CPC Class Codes: A61M 1/3465 using dialysate as substitution fluid
• CPC Class Codes: A61M 1/3623 Means for actively controlling temperature of blood
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3324 PH measuring means
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir
• CPC Class Codes: B01D 61/243 Dialysis
• CPC Class Codes: B01D 61/244 comprising multiple dialysis steps

Abstract

A method and a device to increase the efficiency of dialysis for the removal from blood of substances that are more or less tightly bound to carriers such as albumin. According to the invention this is accomplished by a simultaneous significant increase of the flow rate of the dialysis fluid and of the area of the membrane that separates the blood from the dialysis fluid, compared to conventional dialysis.

Claims

1. A method for removing partially carrier bound substances from blood comprising a blood circuit, a fluid circuit, and a filter having a semipermeable membrane separating a fluid compartment from a blood compartment, where blood is directed through the blood compartment and a cleaning fluid is directed through the fluid compartment wherein:

a mass transfer coefficient k_oA of the filter is at least 2000 ml/min;

a ratio between the mass transfer coefficient k_oA of the filter and a blood flow rate is at least 5; and

the cleaning fluid contains a carrier that is able to bind the partially carrier bound substances in the blood.

2. A method according to claim 1, wherein the membrane has been pretreated with a fluid containing a carrier that is able to bind the partially carrier bound substances in the blood.

3. A method according to claim 1, wherein the carrier is serum albumin.

4. A method according to claim 3 wherein the concentration of the serum albumin is above 10 g/l.

5. A device configured to remove partially carrier bound substances from blood comprising a blood circuit, a fluid circuit, and a filter having a semipermeable membrane separating a fluid compartment from a blood compartment, where blood is directed through the blood compartment and a cleaning fluid is directed through the fluid compartment wherein:

a mass transfer coefficient k_oA of the filter is at least 2000 ml/min;

a ratio between the mass transfer coefficient k_oA of the filter and a blood flow rate is at least 5; and

the cleaning fluid contains a carrier that is able to bind the partially carrier bound substances in the blood.

6. A device according to claim 5, wherein the membrane has been pretreated with a fluid containing a carrier that is able to bind the partially carrier bound substances in the blood.

7. A device according to claim 5 wherein the carrier is serum albumin.

8. A device according to claim 7, wherein the concentration of the serum albumin is above 10 g/l.