Techniques to improve polyurethane membranes for implantable glucose sensors

  • US 8,050,731 B2
  • Filed: 11/16/2005
  • Issued: 11/01/2011
  • Est. Priority Date: 05/22/2002
  • Status: Active Grant
First Claim
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1. An implantable electrochemical sensor for measuring glucose in a bodily fluid, the sensor comprising:

  • at least one electrode having at least a portion configured to be implanted in a host; and

    a membrane disposed over the at least one electrode, the membrane comprising;

    a first layer comprising a blend of (i) a hydrophobic polymer that forms a hydrophobic matrix and (ii) a hydrophobic-hydrophilic copolymer comprising hydrophilic polymer segments that traverse a thickness of the first layer, wherein the first layer is further configured to reduce a flux of glucose through the membrane, wherein the hydrophobic polymer and the hydrophobic-hydrophilic copolymer are soluble with each other, and wherein the hydrophilic polymer segments comprise hydrophilic microdomains that are substantially distributed evenly throughout the hydrophobic matrix; and

    a second layer comprising an enzyme capable of reacting with glucose, wherein the second layer is more proximal to the electrode than the first layer.

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