Systems and methods for delivery of peritoneal dialysis (PD) solutions
First Claim
1. A container system for peritoneal dialysis (PD) solutions, comprising:
- a first compartment containing a first PD agent,a second compartment containing a second PD agent, the second compartment being in any of direct and indirect fluid coupling with the first compartment,an outlet fluid pathway coupled to the second compartment being in any of direct and indirect fluid coupling with an external environment to the container system, anda first seal that prevents fluid transfer between the first compartment and the second compartment,a second seal that prevents fluid transfer to the outlet fluid pathway,the container system further configured to inhibit breaking of the second seal prior to mixing of at least a portion of the first PD agent and the second PD agent.
1 Assignment
0 Petitions
Reexamination
Accused Products
Abstract
The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient'"'"'s abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.
132 Citations
67 Claims
-
1. A container system for peritoneal dialysis (PD) solutions, comprising:
-
a first compartment containing a first PD agent, a second compartment containing a second PD agent, the second compartment being in any of direct and indirect fluid coupling with the first compartment, an outlet fluid pathway coupled to the second compartment being in any of direct and indirect fluid coupling with an external environment to the container system, and a first seal that prevents fluid transfer between the first compartment and the second compartment, a second seal that prevents fluid transfer to the outlet fluid pathway, the container system further configured to inhibit breaking of the second seal prior to mixing of at least a portion of the first PD agent and the second PD agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
-
-
44. A container system for peritoneal dialysis (PD) solutions, comprising:
-
A. a first compartment containing a first PD agent, B. a second compartment containing a second PD agent, the second compartment being in any of direct and indirect fluid coupling with the first compartment, C. a first seal that prevents fluid transfer between the first compartment and the second compartment, D. a second seal that prevents fluid transfer between the second compartment and an outlet fluid pathway of the container system, and E. a protective member configured to inhibit breaking of the second seal prior to breaking of the first seal. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
-
-
57. A container system for peritoneal dialysis (PD) solutions, comprising:
-
A. a first vessel defining a first compartment that contains a first PD agent, B. a second vessel defining a second compartment that contains a second PD agent, the second compartment being in any of direct and indirect fluid coupling with the first compartment, C. a first frangible seal that prevents fluid transfer between the first compartment and the second compartment, D. a second frangible seal that prevents fluid transfer between the second compartment and an outlet fluid pathway of the container system, and E. the second frangible seal being disposed within the second compartment, and wherein a presence of a quantity of buffer agent in the second compartment prior to breaking of the first seal inhibits breaking of the second seal. - View Dependent Claims (58, 59, 60, 61)
-
-
62. A container system for peritoneal dialysis (PD) solutions, comprising:
-
A. a first vessel defining a first compartment that contains a PD osmotic agent, B. a second vessel defining a second compartment that contains a PD buffer agent, the second compartment being in any of direct and indirect fluid coupling with the first compartment, C. a first frangible seal that prevents fluid transfer between the first compartment and the second compartment, D. a second frangible seal that prevents fluid transfer between the second compartment and an outlet fluid pathway of the container system, E. a piercing member, F. the second frangible seal and the piercing member being disposed within the second compartment and being arranged such that compression of that compartment results in breaking of the second seal by the piercing member. - View Dependent Claims (63, 64, 65, 66, 67)
-
Specification