Lipid formulations for nucleic acid delivery

CAFC
  • US 8,058,069 B2
  • Filed: 04/15/2009
  • Issued: 11/15/2011
  • Est. Priority Date: 04/15/2008
  • Status: Active Grant
First Claim
Patent Images

1. A nucleic acid-lipid particle comprising:

  • (a) a nucleic acid;

    (b) a cationic lipid comprising from 50 mol % to 65 mol % of the total lipid present in the particle;

    (c) a non-cationic lipid comprising a mixture of a phospholipid and cholesterol or a derivative thereof, wherein the phospholipid comprises from 4 mol % to 10 mol % of the total lipid present in the particle and the cholesterol or derivative thereof comprises from 30 mol % to 40 mol % of the total lipid present in the particle; and

    (d) a conjugated lipid that inhibits aggregation of particles comprising from 0.5 mol % to 2 mol % of the total lipid present in the particle.

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