Methods and compositions for the treatment of CNS-related conditions

  • US 8,058,291 B2
  • Filed: 04/06/2006
  • Issued: 11/15/2011
  • Est. Priority Date: 04/06/2005
  • Status: Active Grant
First Claim
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1. A method of treating a CNS-related condition comprising orally administering once a day to a human subject in need thereof:

  • (a) 5-40 mg memantine or a pharmaceutically acceptable salt thereof provided in an extended release dosage form, wherein said extended release memantine or pharmaceutically acceptable salt thereof provides a change in plasma concentration as a function of time (dC/dT) that is less than about 50% of the dC/dT of the same quantity of an immediate release form of memantine, wherein the dC/dT is measured in a single dose human PK study between the time period of 0 to Tmax of the immediate release form of memantine; and

    (b) a therapeutically effective amount of donepezil or a pharmaceutically acceptable salt thereof, wherein the CNS-related condition is selected from the group consisting of Alzheimer'"'"'s disease and dementia.

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