Methods and compositions for increasing the anaerobic working capacity in tissues

• US 8,067,381 B1
• Filed: 08/22/2011
• Issued: 11/29/2011
• Est. Priority Date: 08/12/1996
• Status: Expired due to Fees

• Current Assignee: Natural Alternatives International Incorporated (Natural Alternatives LLC)
• Original Assignee: Natural Alternatives International Incorporated (Natural Alternatives LLC)
• Inventors: Dunnett, Mark, Harris, Roger
• Primary Examiner(s): HENLEY III, RAYMOND J
• Application Number:
  US13/215,073
• Publication Number:
  US 20110312882A1
• Time in Patent Office: 99 Days
• Field of Search: 514/21.91, 514/400, 514/561, 514/565
• US Class Current: 514/21.91
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23P 10/40 free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added A23P10/20, A23P10/30 take precedence
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/175 having the group , >N—C(O)—N=N— or , e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/197 the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid carnitine A61K31/205
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/385 having two or more sulfur atoms in the same ring
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/4172 Imidazole-alkanecarboxylic acids, e.g. histidine
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61K 38/05 Dipeptides
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 21/06 Anabolic agents androgens A61P5/26
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Provided are compositions comprising beta-alanylhistidine peptides and/or beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-alanine and/or creatine.

Claims

1. A human dietary supplement comprising at least one of:

an amino acid wherein said amino acid is beta-alanine that is not part of a dipeptide, polypeptide or oligopeptide;

an ester of beta-alanine that is not part of a dipeptide, polypeptide or oligopeptide;

or

an amide of beta-alanine that is not part of a dipeptide, polypeptide or oligopeptide.

2. The human dietary supplement of claim 1, further comprising a carbohydrate.

3. The human dietary supplement of claim 2, wherein the carbohydrate is a simple carbohydrate.

4. The human dietary supplement of claim 3, wherein the simple carbohydrate is glucose.

5. The human dietary supplement of claim 1, further comprising L-Histidine.

6. The human dietary supplement of claim 1, further comprising insulin.

7. The human dietary supplement of claim 1, further comprising an insulin stimulating agent.

8. The human dietary supplement of claim 1, further comprising creatine.

9. The human dietary supplement of claim 1, wherein the creatine is creatine monohydrate.

10. The human dietary supplement of claim 1, wherein the dietary supplement is in liquid form.

11. The human dietary supplement of claim 1, wherein the dietary supplement is in solid form.

12. The human dietary supplement of claim 1, wherein the dietary supplement is in an ingestible suspension.

13. The human dietary supplement of claim 1, wherein the human dietary supplement is effective in delaying the onset of fatigue in a human.

14. The human dietary supplement of claim 1, wherein the human dietary supplement is effective in protecting the function of a creatine-phosphorylcreatine system.