Method for controlling body fluid condition using diuretics, based on weight measurement

• US 8,070,742 B2
• Filed: 08/29/2008
• Issued: 12/06/2011
• Est. Priority Date: 09/01/2007
• Status: Expired due to Fees

• Current Assignee: Sang Hoon Woo
• Original Assignee: Sang Hoon Woo
• Inventors: Woo, Sang Hoon
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): Zhang, Jenna
• Application Number:
  US12/202,072
• Publication Number:
  US 20090062727A1
• Time in Patent Office: 1,194 Days
• Field of Search: 604 65- 67
• US Class Current: 604/503
• CPC Class Codes: A61M 2202/0496 Urine
• CPC Class Codes: A61M 2205/05 combined with other kinds of therapy
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

The system for controlling body fluids overcomes the limitations of the prior art by automatically infusing diuretic and/or other drugs into a human patient. In one approach, the rate of infusion of the diuretic is adjusted based on the measured weight of the patient. For example, this weight can be transmitted wirelessly to a portable diuretic infusion device attached to the patient.

Claims

1. A method of automatically infusing diuretic to an ambulatory human patient at home comprising:

attaching a diuretic infusion device to the body of the ambulatory human patient;

receiving weight information based on body weight measurements performed by the patient to measure his body weight;

adjusting an infusion rate of diuretic into the patient based on the received weight information according to a predetermined protocol wherein;

a program

calculates a difference between a target weight

and a measured weight;

determines a rate of an initial diuretic infusion;

adjusts the rate of diuretic infusion using a diuretic infusion protocol chosen among a plurality of diuretic infusion protocols; and

calculates a difference between the target weight and measured weights at different time points within a day; and

a controller controls a pump based on one of the measured weight of the patient thereby controlling a rate of infusion of the diuretic according to the program to maintain the target weight by adjusting the rate of diuretic infusion until one of the measured weights reaches near the target weight;

wherein the adjustment of the diuretic infusion rate starts after a measured weight information is put into the diuretic infusion device, adjusting the diuretic infusion rate with each of the weight measurements at the different time points, and continues adjusting the infusion rate until one of the measured weight reaches near the target weight; and

infusing the diuretic subcutaneously in the human body at the infusion rate determined by the program.

2. The method of claim 1 wherein the predetermined protocol specifies an infusion rate to maintain the body weight of the patient at a target weight.

3. The method of claim 1 wherein the predetermined protocol specifies an infusion rate to maintain the body weight of the patient within a target weight range.

4. The method of claim 1 wherein the predetermined protocol specifies an infusion rate that does not exceed an upper limit.

5. The method of claim 1 wherein the predetermined protocol specifies an infusion rate that does not fall below a lower limit.

6. The method of claim 1 wherein the predetermined protocol specifies no infusion of the diuretic if the measured body weight is less than a predetermined weight.

7. The method of claim 1 wherein the set of predetermined protocols includes a low dose protocol, a moderate dose protocol, and a high dose protocol.

8. The method of claim 1 wherein the predetermined protocol specifies an infusion rate that increases monotonically as a function of the difference between the measured body weight and a target body weight.

9. The method of claim 8 wherein the infusion rate is proportional to the weight difference.

10. The method of claim 8 wherein the infusion rate is piecewise constant but monotonically increasing as a function of the weight difference.

11. The method of claim 1 wherein the infusion rate includes a bolus rate.

12. The method of claim 1 wherein the infusion rate includes a basal rate.

13. The method of claim 1 wherein the step of receiving weight information comprises wirelessly receiving the weight information.

14. The method of claim 1 wherein the predetermined protocol is further based on a biological parameter other than body weight.

15. The method of claim 1 wherein the predetermined protocol specifies the infusion rate based on body weight measurements taken at two or more different times.

16. The method of claim 1 wherein the predetermined protocol specifies the infusion rate based on an average of body weight measurements taken at two or more different times.

17. The method of claim 1 wherein the predetermined protocol specifies an alarm if the measured body weight exceeds an upper limit.

18. A method of automatically infusing diuretic to an ambulatory human patient at home comprising:

attaching a diuretic infusion device to the body of the ambulatory human patient;

receiving weight information based on body weight measurements performed by the patient to measure his body weight;

adjusting an infusion rate of diuretic into the patient based on the received weight information according to a predetermined protocol wherein;

a program

calculates a difference between a target weight and a measured weight;

determines a rate of an initial diuretic infusion;

adjusts the rate of diuretic infusion using a diuretic infusion protocol chosen among a plurality of diuretic infusion protocols; and

calculates a difference between the target weight and measured weights at different time points within a day; and

a controller controls a pump based on one of the a measured weight of the patient thereby controlling a rate of infusion of the diuretic according to the program to maintain the target weight by adjusting the infusion rate of the diuretic when the measured weight is different from the target weight;

adjusting the rate of diuretic infusion until one of the measured weights reaches near the target weight;

wherein the adjustment of the diuretic infusion rate starts when a measured weight information is put into the diuretic infusion device, adjusting the diuretic infusion rate with each of the weight measurements at the different time points, and continues adjusting the infusion rate until one of the measured weight reaches near the target weight;

displaying the calculated infusion rate to the patient; and

infusing the diuretic subcutaneously into the human body at the infusion rate determined by the program.

19. The method of claim 18 further comprising:

transmitting the weight information to the patient'"'"'s healthcare provider.

20. The method of claim 18 further comprising:

recording the weight information.