Ketoreductases and uses thereof

CAFC
  • US 8,071,347 B2
  • Filed: 09/14/2010
  • Issued: 12/06/2011
  • Est. Priority Date: 02/08/2007
  • Status: Active Grant
First Claim
Patent Images

1. An isolated or engineered polynucleotide encoding a recombinant polypeptide capable of converting acetophenone to (R)-1-phenylethanol which comprises an amino acid sequence with at least 90% sequence identity to SEQ ID NO:

  • 2 or SEQ ID NO;

    4 and having (a) an aromatic amino acid or G at the amino acid residue corresponding to residue 94 of SEQ ID NO;

    2 or SEQ ID NO;

    4, or (b) an amino acid other than S and N at the amino acid residue corresponding to residue 96 of SEQ ID NO;

    2 or SEQ ID NO;

    4.

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