Gene detection assay for improving the likelihood of an effective response to a HER2 antibody cancer therapy

  • US 8,076,066 B2
  • Filed: 03/23/2007
  • Issued: 12/13/2011
  • Est. Priority Date: 05/19/2000
  • Status: Expired due to Term
First Claim
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1. A method of identifying and treating a breast cancer patient disposed to respond favorably to a HER2 antibody, huMAb4D5-8, which method comprises detecting her2 gene amplification in cancer cells in a breast tissue sample from the patient and treating the patient with her2 gene amplification with the HER2 antibody in an amount effective to treat the breast cancer, wherein the patient'"'"'s cancer cells express HER2 at a 0 or 1+ level by immunohistochemistry.

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