Implantable prosthetic valve with non-laminar flow
First Claim
1. A method for implanting a prosthetic valve in a native heart valve, comprising:
- providing a delivery catheter and prosthetic valve, the delivery catheter having the prosthetic valve mounted thereon, the prosthetic valve comprising a support stent and a valve assembly, the support stent comprising an inlet portion at a stent distal end and having an inlet diameter, an outlet portion at a stent proximal end and having an outlet diameter, and a middle portion having a middle diameter, wherein the valve assembly comprises a conduit formed of pliable material, the conduit comprising a conduit inlet end having a conduit inlet end diameter, the conduit further comprising a conduit outlet end having a conduit outlet end diameter, wherein the conduit is positioned within the support stent with the conduit outlet end distal of the conduit inlet end;
advancing the prosthetic valve to the native heart valve; and
radially expanding the support stent in the native heart valve to thereby deploy the prosthetic valve at the native heart valve, wherein radially expanding the support stent comprising radially expanding the support stent such that the middle diameter is greater than the outlet diameter, and the middle diameter is greater than the inlet diameter, wherein the radially expanded stent supports the conduit to have an open configuration wherein fluid flow is permitted distally through the valve assembly and to have a closed configuration wherein fluid flow is blocked through the valve assembly, and when the conduit is in the open configuration the conduit outlet end is positioned radially inwardly from the interior surface of the support stent by a radial distance from 0.5 to 3 cm;
wherein the valve assembly comprises collapsible slack leaflet portions, wherein the conduit of the valve assembly is secured to the support stent via a connecting membrane such that when the prosthetic valve is deployed the entirety of one or more collapsible slack leaflet portions is held away from the support stent interior surface to form an artificial sinus between the support stent interior surface and the collapsible slack leaflet portions.
1 Assignment
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Accused Products
Abstract
A valve prosthesis device is disclosed suitable for implantation in body ducts. The device comprises a support stent adapted to be initially crimped in a narrow configuration for catheterization through the body duct to a target location and adapted to be deployed to a deployed state in the target location, and a valve assembly comprising a flexible conduit having an inlet end and an outlet, made of pliant material providing collapsible slack portions of the conduit at the outlet. When flow is allowed to pass through the valve prosthesis device from the inlet to the outlet the valve assembly is kept in an open position, whereas a reverse flow is prevented. The device is configured so that retrograde flow will be altered from laminar flow and directed towards the leaflets to effect closing. The device can be deployed in a native heart valve position using a deployment catheter.
345 Citations
16 Claims
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1. A method for implanting a prosthetic valve in a native heart valve, comprising:
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providing a delivery catheter and prosthetic valve, the delivery catheter having the prosthetic valve mounted thereon, the prosthetic valve comprising a support stent and a valve assembly, the support stent comprising an inlet portion at a stent distal end and having an inlet diameter, an outlet portion at a stent proximal end and having an outlet diameter, and a middle portion having a middle diameter, wherein the valve assembly comprises a conduit formed of pliable material, the conduit comprising a conduit inlet end having a conduit inlet end diameter, the conduit further comprising a conduit outlet end having a conduit outlet end diameter, wherein the conduit is positioned within the support stent with the conduit outlet end distal of the conduit inlet end; advancing the prosthetic valve to the native heart valve; and radially expanding the support stent in the native heart valve to thereby deploy the prosthetic valve at the native heart valve, wherein radially expanding the support stent comprising radially expanding the support stent such that the middle diameter is greater than the outlet diameter, and the middle diameter is greater than the inlet diameter, wherein the radially expanded stent supports the conduit to have an open configuration wherein fluid flow is permitted distally through the valve assembly and to have a closed configuration wherein fluid flow is blocked through the valve assembly, and when the conduit is in the open configuration the conduit outlet end is positioned radially inwardly from the interior surface of the support stent by a radial distance from 0.5 to 3 cm; wherein the valve assembly comprises collapsible slack leaflet portions, wherein the conduit of the valve assembly is secured to the support stent via a connecting membrane such that when the prosthetic valve is deployed the entirety of one or more collapsible slack leaflet portions is held away from the support stent interior surface to form an artificial sinus between the support stent interior surface and the collapsible slack leaflet portions. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for implanting a prosthetic valve in a target location in a patient'"'"'s heart, comprising:
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providing a delivery catheter and prosthetic valve, the delivery catheter having the prosthetic valve mounted thereon, the prosthetic valve comprising a support stent and a valve assembly, the support stent comprising a first end portion having a first end diameter, a second end portion having a second end diameter, and a middle portion having a middle diameter, wherein the first end portion is a distal end portion and the second end portion is a proximal end portion, wherein the valve assembly comprises a conduit formed from pliable material, the conduit comprising a conduit inlet end and a conduit outlet end, wherein the conduit is positioned within the middle portion of the support stent with the conduit outlet end distal of the conduit inlet end and with the conduit outlet end proximal of the support stent distal end portion; advancing the prosthetic valve to the desired target location in the patient'"'"'s heart; and radially expanding the support stent to thereby implant the prosthetic valve at the desired target location, wherein the support stent is expanded such that the middle diameter is greater than the second end diameter and the first end diameter, wherein the stent is expanded to support the conduit to have an open configuration wherein fluid flow is permitted distally through the valve assembly and to have a closed configuration wherein fluid flow is blocked through the valve assembly, wherein the support stent is expanded such that the conduit in the open configuration at the conduit outlet end is positioned radially inwardly from the interior surface of the support stent by a radial distance from 0.5 to 3 cm; wherein the valve assembly comprises collapsible slack leaflet portions, wherein the conduit of the valve assembly is secured to the support stent via a connecting membrane such that when the prosthetic valve is deployed the entirety of one or more collapsible slack leaflet portions is held away from the support stent interior surface to form an artificial sinus between the support stent interior surface and the collapsible slack leaflet portions. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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Specification