Systems, methods, and computer program products for analysis of vessel attributes for diagnosis, disease staging, and surgical planning
First Claim
1. A method for analyzing blood vessel attributes, the method comprising:
- (a) developing an atlas including at least one blood vessel attribute from blood vessel image data from a population including a plurality of different individuals, wherein developing an atlas includes developing a map of the at least one blood vessel attribute for the population, each location in the map indicating a statistical value of the at least one blood vessel attribute for the population, wherein developing an atlas of blood vessel attributes includes registering blood vessel image data for the different individuals to a template, wherein the template represents an average of blood vessel image data for the individuals;
(b) obtaining blood vessel attribute measurements for an individual subject;
(c) comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas, wherein comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas includes comparing a map of the at least one blood vessel attribute for the individual to the statistical values at corresponding locations in the atlas; and
(d) based on the comparison, determining a physical characteristic of the individual subject.
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Accused Products
Abstract
Systems, methods, and computer program products for analysis of vessel attributes for diagnosis, disease staging, and surgical planning are disclosed. A method for analyzing blood vessel attributes may include developing an atlas including statistical measures for at least one blood vessel attribute. The statistical measures can be developed from blood vessel image data from different individuals. Blood vessel attribute measurements can be obtained from an individual subject. The individual subject'"'"'s blood vessel attribute measurements can be compared to the statistical measures in the atlas. Output may be produced indicative of a physical characteristic of the individual based on results from the comparison.
113 Citations
56 Claims
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1. A method for analyzing blood vessel attributes, the method comprising:
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(a) developing an atlas including at least one blood vessel attribute from blood vessel image data from a population including a plurality of different individuals, wherein developing an atlas includes developing a map of the at least one blood vessel attribute for the population, each location in the map indicating a statistical value of the at least one blood vessel attribute for the population, wherein developing an atlas of blood vessel attributes includes registering blood vessel image data for the different individuals to a template, wherein the template represents an average of blood vessel image data for the individuals; (b) obtaining blood vessel attribute measurements for an individual subject; (c) comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas, wherein comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas includes comparing a map of the at least one blood vessel attribute for the individual to the statistical values at corresponding locations in the atlas; and (d) based on the comparison, determining a physical characteristic of the individual subject. - View Dependent Claims (2, 3, 4, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 51, 52, 53, 54, 55, 56)
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5. A method for analyzing blood vessel attributes, the method comprising:
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(a) developing an atlas including at least one blood vessel attribute from blood vessel image data from a population including a plurality of different individuals, wherein developing an atlas includes developing a map of the at least one blood vessel attribute for the population, each location in the map indicating a statistical value of the at least one blood vessel attribute for the population; (b) obtaining blood vessel attribute measurements for an individual subject, wherein obtaining blood vessel attribute measurements from an individual subject includes; (a) obtaining blood vessel image data for the individual subject; and (b) segmenting the blood vessel image data for the individual subject; (c) comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas, wherein comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas includes comparing a map of the at least one blood vessel attribute for the individual to the statistical values at corresponding locations in the atlas, wherein comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas includes registering the segmented blood vessel image data for the subject with the atlas and computing z-score values comparing the individual subject'"'"'s blood vessel image data with corresponding data in the atlas; and (d) based on the comparison, determining a physical characteristic of the individual subject.
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6. A method for analyzing blood vessel attributes, the method comprising:
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(a) developing an atlas including at least one blood vessel attribute from blood vessel image data from a population including a plurality of different individuals, wherein developing an atlas includes developing a map of the at least one blood vessel attribute for the population, each location in the map indicating a statistical value of the at least one blood vessel attribute for the population; (b) obtaining blood vessel attribute measurements for an individual subject, wherein obtaining blood vessel attribute measurements from an individual subject includes; (a) obtaining blood vessel image data for the individual subject; and (b) segmenting the blood vessel image data for the individual subject; (c) comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas, wherein comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas includes comparing a map of the at least one blood vessel attribute for the individual to the statistical values at corresponding locations in the atlas, wherein comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas includes registering the segmented blood vessel image data for the subject with the atlas and computing z-score values comparing the individual subject'"'"'s blood vessel image data with corresponding data in the atlas, wherein computing z-score values includes computing voxel-by-voxel z-score values for the individual subject'"'"'s blood vessel image data; and (d) based on the comparison, determining a physical characteristic of the individual subject.
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7. A method for analyzing blood vessel attributes, the method comprising:
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(a) developing an atlas including at least one blood vessel attribute from blood vessel image data from a population including a plurality of different individuals, wherein developing an atlas includes developing a map of the at least one blood vessel attribute for the population, each location in the map indicating a statistical value of the at least one blood vessel attribute for the population, wherein the population includes randomly-selected individuals; (b) obtaining blood vessel attribute measurements for an individual subject; (c) comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas, wherein comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas includes comparing a map of the at least one blood vessel attribute for the individual to the statistical values at corresponding locations in the atlas; and (d) based on the comparison, determining a physical characteristic of the individual subject.
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18. A system for analyzing blood vessel attributes, the system comprising:
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(a) an atlas of blood vessel anatomy, the atlas including a map of at least one blood vessel attribute developed from in vivo blood vessel image data from a population including a plurality of different individuals, each location in the map indicating a statistical value of the at least one blood vessel attribute for the population developed by registering blood vessel image data for the different individuals to a template, wherein the template represents an average of blood vessel image data for the individuals; (b) an attribute measurement module for obtaining a blood vessel attribute measurement for an individual subject; (c) an individual subject attribute comparator for comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas, wherein comparing an individual subject'"'"'s blood vessel attribute measurements to the atlas includes comparing a map of the at least one blood vessel attribute for the individual to the statistical values at corresponding locations in the atlas; and (d) an output module for outputting results of the comparison, wherein the results of the comparison indicate a physical characteristic of the individual subject and wherein at least one of the atlas, the attribute measurement module, the comparator, and the output module is embodied in a non-transitory computer readable medium. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26)
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27. A non-transitory computer readable medium having stored thereon computer executable instructions that when executed by the processor of a computer perform steps comprising:
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(a) developing an atlas including at least one blood vessel attribute from in vivo blood vessel image data from a population including a plurality of different individuals, wherein developing an atlas includes developing a map of the at least one blood vessel attribute for the population, each location in the map indicating a statistical value of the at least one blood vessel attribute for the population, wherein developing an atlas of blood vessel attributes includes registering blood vessel image data for the different individuals to a template, wherein the template represents an average of blood vessel image data for the individuals; (b) obtaining blood vessel attribute measurements for an individual subject; (c) comparing the individual subject'"'"'s blood vessel attribute measurements to the atlas, wherein comparing an individual subject'"'"'s blood vessel attribute measurements to the atlas includes comparing a map of the at least one blood vessel attribute for the individual to the statistical values at corresponding locations in the atlas; and (d) based on the comparison, determining a physical characteristic of the individual subject. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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Specification