2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and its uses

• US 8,093,232 B2
• Filed: 07/09/2007
• Issued: 01/10/2012
• Est. Priority Date: 11/22/2004
• Status: Active Grant

• Current Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: DeLuca, Hector F., Sicinski, Rafal R., Plum, Lori A., Clagett-Dame, Margaret
• Primary Examiner(s): Qazi, Sabiha
• Application Number:
  US11/775,074
• Publication Number:
  US 20070254857A1
• Time in Patent Office: 1,646 Days
• Field of Search: 552/653, 514/167
• US Class Current: 514/167
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 5/18 of the parathyroid hormones
• CPC Class Codes: A61P 9/12 : Antihypertensives
• CPC Class Codes: C07C 401/00 : Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
• CPC Class Codes: C07F 7/1804 : Compounds having Si-O-C linkages Si-O-acyl linkages C07F7/1896

Abstract

This invention discloses 2α-methyl-19-nor-(20S)-vitamin D analogs, and specifically 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.

Claims

1. A compound having the formula:

2. The compound of claim 1 wherein X₂ is hydrogen.

3. The compound of claim 1 wherein X₁ is hydrogen.

4. The compound of claim 1 wherein X₁ and X₂ are both t-butyldimethylsilyl.

5. A pharmaceutical composition containing an effective amount of at least one compound as claimed in claim 1 together with a pharmaceutically acceptable excipient.

6. The pharmaceutical composition of claim 5 wherein said effective amount comprises from about 0.01 μ

g to about 1000 μ

g per gram of composition.

7. The pharmaceutical composition of claim 5 wherein said effective amount comprises from about 0.1 μ

g to about 500 μ

g per gram of composition.

8. A method of treating psoriasis comprising administering to a subject with psoriasis an effective amount of a compound having the formula:

9. The method of claim 8 wherein the compound is administered orally.

10. The method of claim 8 wherein the compound is administered parenterally.

11. The method of claim 8 wherein the compound is administered transdermally.

12. The method of claim 8 wherein the compound is administered topically.

13. The method of claim 8 wherein the compound is administered rectally.

14. The method of claim 8 wherein the compound is administered nasally.

15. The method of claim 8 wherein the compound is administered sublingually.

16. The method of claim 8 wherein the compound is administered in a dosage of from about 0.01 μ

g/day to about 1000 μ

g/day.

17. A method of treating a disease selected from the group consisting of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer comprising administering to a subject with said disease an effective amount of a compound having the formula:

18. The method of claim 17 wherein the compound is administered orally.

19. The method of claim 17 wherein the compound is administered parenterally.

20. The method of claim 17 wherein the compound is administered transdermally.

21. The method of claim 17 wherein the compound is administered rectally.

22. The method of claim 17 wherein the compound is administered nasally.

23. The method of claim 17 wherein the compound is administered sublingually.

24. The method of claim 17 wherein the compound is administered in a dosage of from about 0.01 μ

g/day to about 1000 μ

g/day.

25. A method of treating an autoimmune disease selected from the group consisting of multiple sclerosis, lupus, diabetes mellitus, host versus graft rejection, and rejection of organ transplants, comprising administering to a subject with said disease an effective amount of a compound having the formula:

26. The method of claim 25 wherein the compound is administered orally.

27. The method of claim 25 wherein the compound is administered parenterally.

28. The method of claim 25 wherein the compound is administered transdermally.

29. The method of claim 25 wherein the compound is administered rectally.

30. The method of claim 25 wherein the compound is administered nasally.

31. The method of claim 25 wherein the compound is administered sublingually.

32. The method of claim 25 wherein the compound is administered in a dosage of from about 0.01 μ

g/day to about 1000 μ

g/day.

33. A method of treating an inflammatory disease selected from the group consisting of rheumatoid arthritis, asthma, and inflammatory bowel diseases, comprising administering to a subject with said disease an effective amount of a compound having the formula:

34. The method of claim 33 wherein the compound is administered orally.

35. The method of claim 33 wherein the compound is administered parenterally.

36. The method of claim 33 wherein the compound is administered transdermally.

37. The method of claim 33 wherein the compound is administered rectally.

38. The method of claim 33 wherein the compound is administered nasally.

39. The method of claim 33 wherein the compound is administered sublingually.

40. The method of claim 33 wherein the compound is administered in a dosage of from about 0.01 μ

g/day to about 1000 μ

g/day.

41. A method of treating a skin condition selected from the group consisting of wrinkles, lack of adequate skin firmness, lack of adequate dermal hydration and insufficient sebum secretion which comprises administering to a subject with said skin condition an effective amount of a compound having the formula:

42. The method of claim 41 wherein the compound is administered orally.

43. The method of claim 41 wherein the compound is administered parenterally.

44. The method of claim 41 wherein the compound is administered transdermally.

45. The method of claim 41 wherein the compound is administered topically.

46. The method of claim 41 wherein the compound is administered rectally.

47. The method of claim 41 wherein the compound is administered nasally.

48. The method of claim 41 wherein the compound is administered sublingually.

49. The method of claim 41 wherein the compound is administered in a dosage of from about 0.01 μ

g/day to about 1000 μ

g/day.

50. A method of treating renal osteodystrophy comprising administering to a subject with renal osteodystrophy an effective amount of a compound having the formula:

51. The method of claim 50 wherein the compound is administered orally.

52. The method of claim 50 wherein the compound is administered parenterally.

53. The method of claim 50 wherein the compound is administered transdermally.

54. The method of claim 50 wherein the compound is administered rectally.

55. The method of claim 50 wherein the compound is administered nasally.

56. The method of claim 50 wherein the compound is administered sublingually.

57. The method of claim 50 wherein the compound is administered in a dosage of from about 0.01 μ

g/day to about 1000 μ

g/day.