Methods of treatment and pharmaceutical composition

  • US 8,101,659 B2
  • Filed: 06/27/2008
  • Issued: 01/24/2012
  • Est. Priority Date: 01/17/2002
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition comprising:

  • (i) the AT 1-antagonist valsartan or a pharmaceutically acceptable salt thereof;

    (ii) the NEP inhibitor N-(3-carboxy-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methylbutanoic acid ethyl ester or (2R,4S)-5-biphenyl-4-yl-4(3-carboxy-propionyl amino)-2-methyl-pentanoic acid or a pharmaceutically acceptable salt thereof; and

    (iii) a pharmaceutically acceptable carrier;

    wherein said (i) AT 1-antagonist valsartan or pharmaceutically acceptable salt thereof and said (ii) NEP inhibitor N-(3-carboxy-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methylbutanoic acid ethyl ester or (2R,4S)-5-biphenyl-4-yl-4(3-carboxy-propionyl amino)-2-methyl-pentanoic acid or pharmaceutically acceptable salt thereof, are administered in combination in about a 1;

    1 ratio.

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