Analyte sensing and response system

• US 8,114,023 B2
• Filed: 11/01/2006
• Issued: 02/14/2012
• Est. Priority Date: 07/28/2006
• Status: Active Grant

• Current Assignee: Legacy Emanuel Hospital and Health Center
• Original Assignee: Legacy Emanuel Hospital and Health Center
• Inventors: Ward, W. Kenneth, Wood, Michael D., Duman, Heather M., Nair, Bala
• Primary Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US11/592,034
• Publication Number:
  US 20080027301A1
• Time in Patent Office: 1,931 Days
• Field of Search: 600/347, 600/355
• US Class Current: 600/365
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

Electrochemical systems for measuring an analyte concentration, and correcting any surplus or deficiency in the measured concentration. More specifically, systems for measuring an analyte level in a fluid with an implantable sensor, processing the measurements with an algorithm, and determining an appropriate fluid infusion rate in response to the measurements.

Claims

1. A method of determining a fluid infusion rate for infusing a fluid containing insulin into a user, comprising

using a glucose detection device to monitor concentration of glucose in the user and generating a sensor output signal based on the monitored concentration,

using the sensor output signal to generate a processor input signal,

processing the processor input signal using a fading memory proportional derivative algorithm to generate a processor output signal,

determining a fluid infusion rate based at least partially on the processor output signal wherein the fluid contains insulin,

delivering the fluid containing insulin into the user, and

delivering a glucose-increasing substance to the user when the user'"'"'s glucose concentration is falling at a rate above a pre-determined threshold, and the user'"'"'s glucose concentration has fallen below a pre-determined threshold level.

2. The method of claim 1, wherein the glucose-increasing substance is selected from the following:

(a) glucagon, (b) glucagon-like agent, (c) glucose, and (d) dextrose, and mixtures thereof.

3. The method of claim 1, further comprising receiving the sensor output signal at a transmitter electrically coupled to the sensor, converting the sensor output signal to the processor input signal with the transmitter, and transmitting the processor input signal to the processor with the transmitter.

4. The method of claim 1, wherein determining the fluid infusion rate also is based on at least one of the following traits of the user:

insulin sensitivity, age, body weight, usual total daily insulin dose, or physical adiposity.

5. The method of claim 1 further comprising implanting the glucose detection device in the user.

6. A method of determining a fluid infusion rate for infusing a fluid containing insulin into a user, comprising

using a glucose detection device to monitor concentration of glucose in the user and generating a sensor output signal based on the monitored concentration,

using the sensor output signal to generate a processor input signal,

processing the processor input signal using a fading memory proportional derivative algorithm to generate a processor output signal,

determining the fluid infusion rate based at least partially on the processor output signal,

delivering the fluid containing insulin into the user, and

delivering a glucose-increasing substance to the user when the user'"'"'s glucose concentration is falling, the timing and amount of glucose-increasing substance delivered being based on a proportional error of glucose concentration and a derivative error of glucose concentration.

7. The method of claim 6, wherein the timing and amount of glucose-increasing substance delivered is based at least partially on a fading memory calculation relative to the proportional error.

8. The method of claim 6, wherein the timing and amount of the glucose-increasing substance delivered is based at least partially on a fading memory calculation relative to the derivative error.

9. The method of claim 6, wherein the timing and amount of the glucose-increasing substance delivered is based at least partially on fading memory calculations relative to the proportional error and the derivative error, a longer history being considered relative to the proportional error compared to the history considered for the derivative error.