Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors

  • US 8,135,548 B2
  • Filed: 10/26/2007
  • Issued: 03/13/2012
  • Est. Priority Date: 10/26/2006
  • Status: Active Grant
First Claim
Patent Images

1. A computer implemented method for detecting early signal attenuation in a glucose sensor, comprising:

  • receiving a first plurality of glucose sensor related signals within a first predetermined time period after insertion of the glucose sensor into a user, wherein the first predetermined time period occurs within the first 24 hours of insertion;

    determining a sensitivity of the glucose sensor based on the first plurality of glucose sensor related signals and a blood glucose measurement;

    determining a probability of early signal attenuation associated with the first plurality of glucose sensor related signals;

    determining a sensitivity ratio based on the determined sensitivity of the glucose sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the glucose sensor is manufactured;

    receiving a second plurality of glucose sensor related signals during a second predetermined time period when the determined probability does not exceed a first predetermined threshold level, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time;

    verifying the presence of early signal attenuation when the determined probability exceeds the first predetermined threshold level and the determined sensitivity ratio is less than a second predetermined threshold level; and

    generating a first output signal with a processor associated with the verification of the presence of early signal attenuation.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×