Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors
First Claim
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1. A computer implemented method for detecting early signal attenuation in a glucose sensor, comprising:
- receiving a first plurality of glucose sensor related signals within a first predetermined time period after insertion of the glucose sensor into a user, wherein the first predetermined time period occurs within the first 24 hours of insertion;
determining a sensitivity of the glucose sensor based on the first plurality of glucose sensor related signals and a blood glucose measurement;
determining a probability of early signal attenuation associated with the first plurality of glucose sensor related signals;
determining a sensitivity ratio based on the determined sensitivity of the glucose sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the glucose sensor is manufactured;
receiving a second plurality of glucose sensor related signals during a second predetermined time period when the determined probability does not exceed a first predetermined threshold level, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time;
verifying the presence of early signal attenuation when the determined probability exceeds the first predetermined threshold level and the determined sensitivity ratio is less than a second predetermined threshold level; and
generating a first output signal with a processor associated with the verification of the presence of early signal attenuation.
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Abstract
A computer implemented method for receiving a plurality of analyte sensor related signals, determining a probability of signal attenuation associated with the received plurality of analyte sensor related signals, verifying the presence of signal attenuation when the determined probability exceeds a predetermined threshold level, and generating a first output signal associated with the verification of the presence of signal attenuation is provided. Also provided are systems and kits.
582 Citations
27 Claims
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1. A computer implemented method for detecting early signal attenuation in a glucose sensor, comprising:
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receiving a first plurality of glucose sensor related signals within a first predetermined time period after insertion of the glucose sensor into a user, wherein the first predetermined time period occurs within the first 24 hours of insertion; determining a sensitivity of the glucose sensor based on the first plurality of glucose sensor related signals and a blood glucose measurement; determining a probability of early signal attenuation associated with the first plurality of glucose sensor related signals; determining a sensitivity ratio based on the determined sensitivity of the glucose sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the glucose sensor is manufactured; receiving a second plurality of glucose sensor related signals during a second predetermined time period when the determined probability does not exceed a first predetermined threshold level, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time; verifying the presence of early signal attenuation when the determined probability exceeds the first predetermined threshold level and the determined sensitivity ratio is less than a second predetermined threshold level; and generating a first output signal with a processor associated with the verification of the presence of early signal attenuation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An apparatus, comprising:
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a data storage unit; and a processing unit operatively coupled to the data storage unit configured to receive a first plurality of glucose sensor related signals within a first predetermined time period after insertion of the glucose sensor into a user, wherein the first predetermined time period occurs within the first 24 hours of insertion, determine a sensitivity of the glucose sensor based on the first plurality of glucose sensor related signals and a blood glucose measurement, determine a probability of early signal attenuation associated with the first plurality of glucose sensor related signals, determine a sensitivity ratio based on the determined sensitivity of the glucose sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the glucose sensor is manufactured, receive a second plurality of glucose sensor related signals during a second predetermined time period when the determined probability does not exceed a first predetermined threshold level, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time, verify the presence of early signal attenuation when the determined probability exceeds the first predetermined threshold level and the determined sensitivity ratio is less than a second predetermined threshold level, and generate a first output signal associated with the verification of the presence of early signal attenuation. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A system for detecting early signal attenuation in a glucose sensor, comprising:
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a glucose sensor for transcutaneous positioning through a skin layer of a user; and a data processing device operatively coupled to the glucose sensor, the data processing device configured to receive a first plurality of glucose sensor related signals within a first predetermined time period after insertion of the glucose sensor into the user, wherein the first predetermined time period occurs within the first 24 hours of insertion, determine a sensitivity of the glucose sensor based on the first plurality of glucose sensor related signals and a blood glucose measurement, determine a probability of the early signal attenuation associated with the first plurality of glucose sensor related signals, determine a sensitivity ratio based on the determined sensitivity of the glucose sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the glucose sensor is manufactured, receive a second plurality of glucose sensor related signals during a second predetermined time period when the determined probability does not exceed a first predetermined threshold level, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time, verify the presence of early signal attenuation when the determined probability exceeds the first predetermined threshold level and the determined sensitivity ratio is less than a second predetermined threshold level, and generate a first output signal associated with the verification of the presence of early signal attenuation. - View Dependent Claims (27)
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Specification