Valve with delayed leaflet deployment

• US 8,137,394 B2
• Filed: 01/14/2011
• Issued: 03/20/2012
• Est. Priority Date: 12/21/2007
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Stocker, Patrick J., Walker, Joseph C.
• Primary Examiner(s): Willse, David H
• Assistant Examiner(s): SHIPMON, TIFFANY P
• Application Number:
  US13/006,578
• Publication Number:
  US 20110118831A1
• Time in Patent Office: 431 Days
• Field of Search: 623/1.24, 623/2.11, 623/2.14
• US Class Current: 623/1.24
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2433 using balloon catheter
• CPC Class Codes: A61F 2/2436 Deployment by retracting a sheath
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2220/0008 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2250/0059 temporary

Abstract

A valve for use in a body lumen, where the valve includes a valve leaflet with delayed leaflet deployment relative an in vivo implant time. The valve includes a valve frame, a valve leaflet coupled to the valve frame. The valve leaflet includes a commissure that can reversibly seal for unidirectional flow of a liquid through the valve, and a biodegradable adhesive between the valve leaflet and the valve frame to hold at least the commissure of the valve leaflet in a static relationship relative the valve frame for a predetermined time once implanted in vivo.

Claims

1. A valve, comprising:

a valve frame;

a valve leaflet coupled to the valve frame and configured for delayed deployment after a predetermined time, the valve leaflet having an open state and a closed state for unidirectional flow of a liquid through the valve after the predetermined time; and

one or more biodegradable adhesives holding the valve leaflet in a static relationship relative the valve frame for uncontrolled flow of the liquid through the valve for the predetermined time, the one or more biodegradable adhesives configured to degrade over the predetermined time to deploy the valve leaflet from the static relationship with the valve frame after the predetermined time,

wherein the one or more biodegradable adhesives are located at different discrete regions along the valve frame extending from a distal end of the valve frame to a proximal end of the valve frame, and

wherein a concentration of the one or more biodegradable adhesives at each of the discrete regions changes from the distal end to the proximal end of the valve frame to progressively release the valve leaflet.

2. The valve of claim 1, wherein the concentration of one or more biodegradable adhesives at the distal end of the valve frame is different than the concentration of the one or more biodegradable adhesives at the proximal end of the valve frame.

3. The valve of claim 1, wherein a proximal end of the valve leaflet is coupled to the valve frame.

4. The valve of claim 3, wherein the proximal end of the valve leaflet is secured to the valve frame by at least one of stitching, bonding, and gluing.

5. The valve of claim 1, wherein the valve includes at least two valve leaflets.

6. The valve of claim 1, wherein the valve includes one or more radiopaque markers.

7. The valve of claim 1 wherein the valve is at least partially balloon expandable, self expandable, or a combination thereof.

8. The valve of claim 1, wherein the valve leaflet is formed of either a biologic material or a synthetic material.

9. The valve of claim 1, wherein the valve is formed of a material with a spring bias.