Methods of using an electrochemical biosensor
First Claim
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1. A method for evaluating whether an electrochemical sensor is properly filled, the electrochemical sensor including a working electrode and a counter electrode, the counter electrode including a high-resistance portion and a low-resistance portion, the high-resistance portion including a resistor, the method comprising:
- introducing the fluid test sample to the electrochemical test sensor;
applying a first potential between a counter electrode and a working electrode for a first predetermined time period after the fluid test sample has electrically connected the working electrode and the counter electrode;
after the first predetermined time period, applying a second potential between the counter electrode and the working electrode for a second predetermined time period, the second potential having a magnitude that is greater than a magnitude of the first potential;
measuring the current between the counter electrode and the working electrode at a first interval during the first predetermined time period to obtain a first current measurement;
measuring the current between the counter electrode and the working electrode at a second interval during the second predetermined period to obtain a second current measurement;
determining a first parameter based on the first current measurement and the second current measurement;
comparing the first parameter to at least one first predetermined parameter; and
notifying a user that an insufficient quantity of fluid test sample has been introduced to the electrochemical test sensor based on the comparing the first parameter to the at least one first predetermined parameter.
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Abstract
According to one embodiment of the present invention, an electrochemical sensor (10) for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor (10) includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.
34 Citations
24 Claims
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1. A method for evaluating whether an electrochemical sensor is properly filled, the electrochemical sensor including a working electrode and a counter electrode, the counter electrode including a high-resistance portion and a low-resistance portion, the high-resistance portion including a resistor, the method comprising:
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introducing the fluid test sample to the electrochemical test sensor; applying a first potential between a counter electrode and a working electrode for a first predetermined time period after the fluid test sample has electrically connected the working electrode and the counter electrode; after the first predetermined time period, applying a second potential between the counter electrode and the working electrode for a second predetermined time period, the second potential having a magnitude that is greater than a magnitude of the first potential; measuring the current between the counter electrode and the working electrode at a first interval during the first predetermined time period to obtain a first current measurement; measuring the current between the counter electrode and the working electrode at a second interval during the second predetermined period to obtain a second current measurement; determining a first parameter based on the first current measurement and the second current measurement; comparing the first parameter to at least one first predetermined parameter; and notifying a user that an insufficient quantity of fluid test sample has been introduced to the electrochemical test sensor based on the comparing the first parameter to the at least one first predetermined parameter. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for evaluating whether an electrochemical test sensor is properly filled, the test sensor including a working electrode electrically coupled to a first lead and a counter electrode electrically coupled to a second lead, the counter electrode including a low-resistance portion and a high-resistance portion, the high-resistance portion including a resistor, the method comprising:
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applying a voltage profile across the first and second leads; measuring the current profile at the first and second leads in response to the applied voltage profile; comparing the measured current profile to a predetermined current profile; and generating an under-filled error signal based on the comparing of the measured current profile to the predetermined profile. - View Dependent Claims (9, 10, 11, 12, 13)
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14. A method for evaluating whether an electrochemical sensor is properly filled, the test sensor including a working electrode coupled to a first lead, and counter electrode coupled to a second lead, the counter electrode including a high-resistance portion and a low-resistance portion, the high-resistance portion including a resistor, the test sensor including a reagent disposed on the working electrode that is adapted to react with glucose in a blood sample for producing an electrochemical reaction indicative of the concentration of the glucose in the blood sample, the method comprising:
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collecting a blood sample; applying a voltage profile across the first and second leads; measuring the current profile at the first and second leads in response to the applied voltage profile; and generating an under-filled error signal when the measured current profile is not of a predetermined shape. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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23. A method for evaluating whether an electrochemical sensor is properly filled, the test sensor including a working electrode coupled to a first lead, and counter electrode coupled to a second lead, the counter electrode including a high-resistance portion and a low-resistance portion, the high-resistance portion including a resistor, the method comprising:
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collecting a blood sample; applying a first potential across the first and second leads for a first predetermined time period; after the first predetermined time period, applying a second potential across the first and second leads for a second predetermined time period, the second potential having a magnitude that is greater than a magnitude of the first potential; and measuring the current at the first and second leads at least one interval in response to the applied first potential and the applied second potential. - View Dependent Claims (24)
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Specification