Non-captured intrinsic discrimination in cardiac pacing response classification

• US 8,145,310 B2
• Filed: 07/07/2008
• Issued: 03/27/2012
• Est. Priority Date: 12/11/2003
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Stalsberg, Kevin John, Dong, Yanting, Meyer, Scott A.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Sarcione, Jessica
• Application Number:
  US12/217,652
• Publication Number:
  US 20080275522A1
• Time in Patent Office: 1,359 Days
• Field of Search: 607/7, 607/9, 607 25- 28, 600/510
• US Class Current: 607/27
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61N 1/371 Capture, i.e. successful stimulation

Abstract

Cardiac devices and methods discriminate non-captured intrinsic beats during evoked response detection and classification by comparing the features of a post-pace cardiac signal with expected features associated with a non-captured response with intrinsic activation. Detection of a non-captured response with intrinsic activation may be based on the peak amplitude and timing of the cardiac signal. The methods may be used to discriminate between a fusion or capture beat and a non-captured intrinsic beat. Discriminating between possible cardiac responses to the pacing pulse may be useful, for example, during automatic capture verification and/or a capture threshold test.

Claims

1. A method of operating a cardiac device to classify a cardiac response to a pacing pulse, comprising:

delivering the pacing pulse to a heart;

sensing a cardiac signal following delivery of the pacing pulse;

determining if a peak of the cardiac signal falls within one of a plurality of detection windows associated with a non-captured, intrinsic response, each of the intrinsic detection windows finitely bounded in time and amplitude;

classifying the cardiac response to the pacing pulse as the non-captured intrinsic response if the cardiac signal peak falls within one of the intrinsic detection windows;

determining if the peak of the cardiac signal falls within a capture detection window finitely bounded by time and amplitude and associated with a captured response;

classifying the cardiac response to the pacing pulse as the captured response if the peak of the cardiac signal falls within the capture detection window and not within an intrinsic detection window; and

delivering pacing therapy based on the cardiac response classification.

2. The method of claim 1, wherein at least one of the intrinsic detection windows is coextensive in amplitude and non-overlapping with respect to a capture detection window, the capture detection window finitely bounded in time and amplitude.

3. The method of claim 1, wherein at least one of the intrinsic detection windows is coextensive in time and non-overlapping with respect to a capture detection window, the capture detection window finitely bounded in time and amplitude.

4. The method of claim 1, wherein:

at least one of the intrinsic detection windows is coextensive in amplitude and non-overlapping with respect to a capture detection window, the capture detection window finitely bounded in time and amplitude; and

at least one of the intrinsic detection windows is coextensive in time and non-overlapping with respect to a capture detection window, the capture detection window finitely bounded in time and amplitude.

5. The method of claim 1, wherein determining if the peak of the cardiac signal falls within a capture detection window comprises:

determining if the peak of the cardiac signal falls within a first capture detection window;

determining if a peak of opposite polarity falls within a second capture detection window, each of the first and second capture detection windows finitely bounded by time and amplitude and associated with a captured response; and

classifying the cardiac response to the pacing pulse as the captured response if the peaks of the cardiac signal respectively fall within the first and second capture detection windows.

6. The method of claim 1, further comprising discriminating the non-captured intrinsic response from unknown cardiac activity.

7. The method of claim 1, further comprising discriminating the cardiac response as a fusion beat if the cardiac response is not a captured beat or a non-captured intrinsic beat.

8. The method of claim 1, further comprising discriminating the non-captured intrinsic response from a premature ventricular activation.

9. The method of claim 1, further comprising:

determining if the cardiac signal peak falls in at least one noise detection window; and

classifying the cardiac response as unknown cardiac signal behavior if the cardiac signal peak is detected in the noise detection window.

10. The method of claim 1, wherein parameters of at least one intrinsic detection window are selected based on patient conditions.

11. A system for classifying a cardiac response to a pacing pulse, comprising:

a sensor system comprising a plurality of electrodes electrically coupled to a heart, the sensor system configured to sense a cardiac signal following delivery of the pacing pulse; and

a processor coupled to the sensing system, the processor configured to determine if a peak of the cardiac signal falls within one of a plurality of detection windows associated with a non-captured intrinsic response, each of the intrinsic detection windows finitely bounded in time and amplitude, the processor further configured to classify the cardiac response to the pacing pulse as the non-captured intrinsic response if the cardiac signal peak falls within one of the intrinsic detection windows, wherein the processor is further configured to determine if the peak of the cardiac signal falls within a capture detection window finitely bounded by time and amplitude and associated with a captured response and to classify the cardiac response to the pacing pulse as the captured response if the peak of the cardiac signal falls within the capture detection window and not within any of the intrinsic detection windows; and

therapy circuit configured to deliver pacing therapy based on the cardiac response classification.

12. The system of claim 11, wherein at least one of the intrinsic detection windows is coextensive in amplitude and non-overlapping with respect to a capture detection window, the capture detection window finitely bounded in time and amplitude.

13. The system of claim 11, wherein at least one of the intrinsic detection windows is coextensive in time and non-overlapping with respect to a capture detection window, the capture detection window finitely bounded in time and amplitude.

14. The system of claim 11, wherein:

at least one of the intrinsic detection windows is coextensive in amplitude and non-overlapping with respect to a capture detection window, the capture detection window finitely bounded in time and amplitude; and

at least one of the intrinsic detection windows is coextensive in time and non-overlapping with respect to a capture detection window, the capture detection window finitely bounded in time and amplitude.

15. The system of claim 11, wherein, to determine if the peak of the cardiac signal falls within the capture detection window, the processor is configured to determine if the peak of the cardiac signal falls within a first capture detection window and to determine if a peak of opposite polarity falls within a second capture detection window, each of the first and second capture detection windows finitely bounded by time and amplitude and associated with a captured response and to classify the cardiac response to the pacing pulse as the captured response if the peaks of the cardiac signal respectively fall within the first and second capture detection windows.

16. The system of claim 11, wherein the processor is further configured to determine if the cardiac signal peak falls in at least one noise detection window and to classify the cardiac response as unknown cardiac signal behavior if the cardiac signal peak is detected in the noise detection window.

17. The system of claim 11, wherein the processor is further configured to discriminate the cardiac response as a fusion beat if the cardiac response is not a captured beat or a non-captured intrinsic beat.

18. The system of claim 11, wherein the processor is further configured to discriminate the non-captured intrinsic response from a premature ventricular activation.

19. A cardiac device, comprising:

a pulse generator configured to deliver a pacing pulse to a heart;

a sensing system configured to sense a cardiac signal following delivery of a pacing pulse;

means for determining if a peak of the cardiac signal falls within one of a plurality of detection windows associated with a non-captured, intrinsic response, each of the intrinsic detection windows finitely bounded in time and amplitude;

means for classifying the cardiac response to the pacing pulse as the non-captured intrinsic response if the cardiac signal peak falls within one of the intrinsic detection windows;

means for determining if the peak of the cardiac signal falls within a capture detection window finitely bounded by time and amplitude and associated with a captured response;

means for classifying the cardiac response to the pacing pulse as the captured response if the peak of the cardiac signal falls within the capture detection window and not within an intrinsic detection window; and

a pulse generator configured to deliver pacing pulses based on the cardiac response classification.

20. The cardiac device of claim 19, further comprising:

means for determining if the peak of the cardiac signal falls within a first capture detection window;

means for determining if a peak of opposite polarity falls within a second capture detection window, each of the first and second capture detection windows finitely bounded by time and amplitude and associated with a captured response; and

means for discriminating between the non-captured intrinsic response and the captured response using the intrinsic and capture detection windows.